4-(4-氯苯氧基)苯乙酮合成路线 （共 14 条）
反应条件
1: 80 percent / NaOCl, HCl / H2O; ethanol 2: 72 percent / H2SO4 / Heating 3: 64 percent / BH3-(CH3)2S / tetrahydrofuran 4: 88 percent / SOCl2 / CHCl3; pyridine / 1 h / 20 °C View Scheme
参考文献
Haydock; Mulholland; Telford; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 3 p. 205 - 214
反应条件
sodium hydrogensulfite in ethanol; water
参考文献
Syntex (U.S.A.) Inc.
Patent: US5034410 A1, 1991 ;
反应条件
hydrogenchloride; sodium hypochlorite in ethanol; water
参考文献
Haydock; Mulholland; Telford; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 3 p. 205 - 214
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20 - 150°C; 24 h;
参考文献
Han, Young Taek; Kim, Kyeojin; Choi, Gyeong-In; An, Hongchan; Son, Dohyun; Kim, Hee; Ha, Hee-Jin; Son, Jun-Hyeng; Chung, Suk-Jae; Park, Hyun-Ju; Lee, Jeewoo; Suh, Young-Ger
European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 128 - 142
反应条件
potassium phosphate; copper(l) iodide; 2-((2-isopropylphenylimino)methyl)phenol in 1,4-dioxane
T=20 - 101°C; Ullmann Condensation; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Qian, Cun-Wei; Lv, Wen-Lin; Zong, Qian-Shou; Wang, Mao-Yuan; Fang, Dong
Chinese Chemical Letters, 2014 , vol. 25, # 2 p. 337 - 340
反应条件
caesium carbonate; silica gel in dichloromethane; ethyl acetate; toluene
参考文献
Massachusetts Institute of Technology
Patent: US6395939 B1, 2002 ;
反应条件
copper (II) acetate monohydrate; caesium carbonate in N,N-dimethyl-formamide
T=100°C; 4 h; Inert atmosphereSchlenk technique;
参考文献
Chen, Jiuxi; Wang, Xingyong; Zheng, Xingwang; Ding, Jinchang; Liu, Miaochang; Wu, Huayue
Tetrahedron, 2012 , vol. 68, # 43 p. 8905 - 8907
反应条件
(CuOTf)2.C6H6; naphthalene-1-carboxylic acid; caesium carbonate; ethyl acetate in toluene
T=110°C;
参考文献
Marcoux; Doye; Buchwald
Journal of the American Chemical Society, 1997 , vol. 119, # 43 p. 10539 - 10540
反应条件
1: 1-bromo-4-(4-chlorophenoxy)benzene With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran
T=0°C; 1 h; Reflux;
2: acetyl chloride in tetrahydrofuran
T=20 - 35°C; 1 h;
参考文献
BASF SE; GRAMMENOS, Wassilios; CRAIG, Ian, Robert; BOUDET, Nadege; MüLLER, Bernd; DIETZ, Jochen; LAUTERWASSER, Erica, May, Wilson; LOHMANN, Jan, Klaas; GROTE, Thomas; HADEN, Egon; ESCRIBANO CUESTA, Ana
Patent: WO2014/82871 A1, 2014 ;
Location in patent: Page/Page column 85 ;
反应条件
potassium phosphate in tetrahydrofuran
T=115°C; 18 h;
参考文献
Ghosh, Rajshekhar; Samuelson, Ashoka G.
New Journal of Chemistry, 2004 , vol. 28, # 11 p. 1390 - 1393
