4-乙酰氨基-5-氯-2-甲氧基苯甲酸酯合成路线 （共 16 条）
反应条件
palladium diacetate; copper diacetate; copper dichloride in dichloromethane T=90°C; 48 h;
参考文献
Wan, Xiaobing; Ma, Zhongxun; Li, Bijie; Zhang, Keya; Cao, Shaokui; Zhang, Shiwei; Shi, Zhangjie
Journal of the American Chemical Society, 2006 , vol. 128, # 23 p. 7416 - 7417
反应条件
acetic acid T=50°C; 5 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 59 ;
US 20120277224 A1
反应条件
hydrogen in palladium monocarbide
参考文献
California Institute of Technology
Patent: US2005/26174 A1, 2005 ;
反应条件
acetic acid in acetic anhydride
参考文献
Rorer Pharmaceutical Corporation
Patent: US4863921 A1, 1989 ;
反应条件
1: H2O / 1.) room temp., 30 min., 2.) 60-70 deg C, 1 h 2: aq. sodium hypochlorite / 1 h View Scheme
参考文献
Pakula; Butkiewicz; Trojanowska; Ruszczak
Archiv der Pharmazie, 1980 , vol. 313, # 4 p. 297 - 300
反应条件
1: sodium hydroxide / N,N-dimethyl-formamide 2: N-chloro-succinimide / N,N-dimethyl-formamide View Scheme
参考文献
Deng, Xin; Zhao, Xinxin; Han, Jing; Wang, Jingjie; Huang, Wenlong; Qian, Hai; Ge, Liang
Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 489 - 493
反应条件
1: sulfuric acid / 2 h / 20 °C 2: acetic acid / 1 h 3: sodium hydroxide / N,N-dimethyl-formamide 4: N-chloro-succinimide / N,N-dimethyl-formamide View Scheme
参考文献
Deng, Xin; Zhao, Xinxin; Han, Jing; Wang, Jingjie; Huang, Wenlong; Qian, Hai; Ge, Liang
Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 489 - 493
反应条件
1: acetic acid / 1 h 2: sodium hydroxide / N,N-dimethyl-formamide 3: N-chloro-succinimide / N,N-dimethyl-formamide View Scheme
参考文献
Deng, Xin; Zhao, Xinxin; Han, Jing; Wang, Jingjie; Huang, Wenlong; Qian, Hai; Ge, Liang
Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 489 - 493
反应条件
1: thionyl chloride / 5 h / 80 °C 2: acetic acid / 5 h / 50 °C View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
反应条件
sodium hydroxide; acetic acid 1.) 90-95 deg C, 4 h, 2.) water, heating; Yield given. Multistep reaction;
参考文献
Pakula; Butkiewicz; Trojanowska; Ruszczak
Archiv der Pharmazie, 1980 , vol. 313, # 4 p. 297 - 300
