4'-正戊基-4-氰基联苯合成路线 （共 23 条）
反应条件
1: With iodine; magnesium in tetrahydrofuran T=70°C; 2: With N,N-dimethyl-formamide in tetrahydrofuran T=0°C; 2 h; 3: With ammonia; iodine in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Ishii, Genki; Harigae, Ryo; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2013 , vol. 69, # 5 p. 1462 - 1469
反应条件
potassium fluoride; palladium diacetate; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide T=120°C;
参考文献
Hatanaka, Yasuo; Goda, Ken-ichi; Okahara, Yoshinori; Hiyama, Tamejiro
Tetrahedron, 1994 , vol. 50, # 28 p. 8301 - 8316
反应条件
1: 4-bromo-4’-pentyl-1,1’-biphenyl With n-butyllithium in tetrahydrofuran; hexane T=-70°C; 2 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0°C; 2 h; 3: With 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; ammonia in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 5 p. 958 - 964
反应条件
1: 96 percent / Mg / tetrahydrofuran / 12 h / Ambient temperature 2: 73 percent / KF / Pd(OAc)2, P(o-Tol)3 / dimethylformamide / 120 °C View Scheme
参考文献
Hatanaka, Yasuo; Goda, Ken-ichi; Okahara, Yoshinori; Hiyama, Tamejiro
Tetrahedron, 1994 , vol. 50, # 28 p. 8301 - 8316
反应条件
in N,N-dimethyl-formamide 6 h; Heating;
参考文献
Dabrowski; Witkiewicz; Kenig
Molecular crystals and liquid crystals, 1980 , vol. 58, # 3-4 p. 251 - 259
反应条件
sodium carbonate in water; ethyl acetate; isopropyl alcohol T=50°C; Suzuki-Miyaura coupling; 0.00138889 h; Microchannel flow reactor;
参考文献
Yamada, Yoichi M. A.; Watanabe, Toshihiro; Beppu, Tomohiko; Fukuyama, Naoshi; Torii, Kaoru; Uozumi, Yasuhiro
Chemistry - A European Journal, 2010 , vol. 16, # 37 p. 11311 - 11319
反应条件
acetic anhydride 2 h; Heating;
参考文献
Ruolene, Yu. I.; Adomenas, P. V.; Sirutkaitis, R. A.; Denis, G. I.
Journal of Organic Chemistry USSR (English Translation), 1984 , vol. 20, p. 1187 - 1191
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 6 p. 1305 - 1310
反应条件
1: 1) hydrazine hydrate, 2) KOH / 1) diethylene glycol, 130 deg C, 1 h, 2) diethylene glycol, 130 deg C, 2 h, then 160 deg C, 3 h 2: 1) TiCl4, 2) hydroxylamine hydrochloride, pyridine / 1) CH2Cl2, 0 deg C, 30 min, 2) ethanol, reflux, 2 h 3: 73 percent / acetic anhydride / 2 h / Heating View Scheme
参考文献
Dabrowski; Witkiewicz; Kenig
Molecular crystals and liquid crystals, 1980 , vol. 58, # 3-4 p. 251 - 259
反应条件
1: 1) TiCl4, 2) hydroxylamine hydrochloride, pyridine / 1) CH2Cl2, 0 deg C, 30 min, 2) ethanol, reflux, 2 h 2: 73 percent / acetic anhydride / 2 h / Heating View Scheme
参考文献
Dabrowski; Witkiewicz; Kenig
Molecular crystals and liquid crystals, 1980 , vol. 58, # 3-4 p. 251 - 259
反应条件
1: AlCl3 / CH2Cl2 / 5 h / Ambient temperature 2: 1) hydrazine hydrate, 2) KOH / 1) diethylene glycol, 130 deg C, 1 h, 2) diethylene glycol, 130 deg C, 2 h, then 160 deg C, 3 h 3: 1) TiCl4, 2) hydroxylamine hydrochloride, pyridine / 1) CH2Cl2, 0 deg C, 30 min, 2) ethanol, reflux, 2 h 4: 73 percent / acetic anhydride / 2 h / Heating View Scheme
参考文献
Dabrowski; Witkiewicz; Kenig
Molecular crystals and liquid crystals, 1980 , vol. 58, # 3-4 p. 251 - 259
