3'-O-(叔丁基二甲基硅烷基)胸苷合成路线 （共 31 条）
反应条件
ammonia in methanol
24 h;
参考文献
Cameron, Melissa A.; Cush, Sarah B.; Hammer, Robert P.
Journal of Organic Chemistry, 1997 , vol. 62, # 26 p. 9065 - 9069
反应条件
lithium boron tetrafluoride in dichloromethane
T=20°C; deprotection; 0.25 h;
参考文献
Chen, Anqi; Zheng, Yong; Zhou, Xinfeng
Synthetic Communications, 1999 , vol. 29, # 19 p. 3421 - 3423
反应条件
1: 95 percent / imidazole / dimethylformamide / 20 °C
2: 81 percent / TFA / CH2Cl2; H2O / 4 h / 0 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1: 92 percent / DMAP; Et3N / dimethylformamide
2: 83 percent / I2; MeOH
View Scheme
参考文献
Charles; Xue, Liang; Arya, Dev P.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 9 p. 1259 - 1262
反应条件
1: 97 percent / diisopropylethylamine / dimethylformamide
2: 89 percent / ZnBr2, CH3OHEi / CHCl3; methanol
View Scheme
参考文献
Kim, Su Jeong; Lee, Ju Young; Kim, Byeang Hyean
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 11 p. 1313 - 1316
参考文献
Isis Pharmaceuticals, Inc.; McGill University
Patent: US6160109 A1, 2000 ;
反应条件
pyridine; water; iodine
0.0833333 h;
参考文献
Utagawa, Eri; Sekine, Mitsuo; Seio, Kohji
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7668 - 7677
反应条件
methanol; formic acid
T=5 - 20°C; Inert atmosphere; chemoselective reaction;
参考文献
Chandra, Tilak; Broderick, William E.; Broderick, Joan B.
Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 11-12 p. 1016 - 1029
反应条件
1: 82 percent / DMAP, Et3N / dimethylformamide / 24 h / Ambient temperature
2: 99 percent / formic acid / diethyl ether / 2 h / 0 °C
View Scheme
参考文献
Magdalena, Julia; Fernandez, Susana; Ferrero, Miguel; Gotor, Vicente
Tetrahedron Letters, 1999 , vol. 40, # 9 p. 1787 - 1790
反应条件
water; acetic acid
Hydrolysis;
参考文献
Satou, Kousuke; Komatsu, Yasuo; Torizawa, Takuya; Kato, Koichi; Shimada, Ichio; Nikaido, Osamu; Ohtsuka, Eiko
Tetrahedron Letters, 2000 , vol. 41, # 13 p. 2175 - 2179
