3,5-双-o-(t-丁基二甲基甲硅烷基)胸腺嘧啶脱氧核苷合成路线 （共 38 条）
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / |Inert atmosphere; |Reflux 2: triethylamine / N,N-dimethyl-formamide / 24 h / 70 °C / |Inert atmosphere 3: water; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / |Inert atmosphere 4: tetrabutyl ammonium fluoride / tetrahydrofuran / |Inert atmosphere 5: water / 0.17 h / |UV-irradiation; |Inert atmosphere View Scheme
参考文献
Lin, Gengjie; Li, Lei
Angewandte Chemie - International Edition, 2013 , vol. 52, # 21 p. 5594 - 5598
Angew. Chem., 2013 , vol. 125, # 21 p. 5704 - 5708,5
反应条件
copper(II) sulfate in xylene Heating;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 27, # 8 p. 931 - 948
反应条件
potassium tert-butylate in N,N-dimethyl-formamide 1 h; Ambient temperature;
参考文献
Negron; Vasquez; Calderon; Cruz; Gavino; Islas
Synthetic Communications, 1998 , vol. 28, # 16 p. 3021 - 3027
反应条件
copper(II) sulfate in xylene Heating;
参考文献
Cabral, Nadia L. D.; Thiessen, Luciano Hoeltgebaum; Doboszewski, Bogdan
Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 8 p. 931 - 948
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / |Inert atmosphere; |Reflux 2: triethylamine / N,N-dimethyl-formamide / 24 h / 70 °C / |Inert atmosphere 3: water; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / |Inert atmosphere 4: tetrabutyl ammonium fluoride / tetrahydrofuran / |Inert atmosphere 5: water / 0.17 h / |UV-irradiation; |Inert atmosphere View Scheme
参考文献
Lin, Gengjie; Li, Lei
Angewandte Chemie - International Edition, 2013 , vol. 52, # 21 p. 5594 - 5598
Angew. Chem., 2013 , vol. 125, # 21 p. 5704 - 5708,5
反应条件
ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane 4 h; Heating;
参考文献
Cameron, Melissa A.; Cush, Sarah B.; Hammer, Robert P.
Journal of Organic Chemistry, 1997 , vol. 62, # 26 p. 9065 - 9069
反应条件
1: N-bromosuccinimide; azoisobutyronitrile / benzene / 0.67 h / 80 °C 2: 61 percent / NaOMe / 2 h 3: 78 percent / Et3N*3HF; pyridine / tetrahydrofuran / 16 h / 20 °C 4: 78 percent / pyridine / 4 h / 20 °C View Scheme
参考文献
Grover, Rajesh K.; Pond, Stephanie J. K.; Cui, Qizhi; Subramaniam, Prem; Case, David A.; Millar, David P.; Wentworth Jr., Paul
Angewandte Chemie - International Edition, 2007 , vol. 46, # 16 p. 2839 - 2843
反应条件
sodium hydride in tetrahydrofuran T=0°C; 16 h;
参考文献
Nishimoto, Atsushi; Jitsuzaki, Daichi; Onizuka, Kazumitsu; Taniguchi, Yosuke; Nagatsugi, Fumi; Sasaki, Shigeki
Nucleic Acids Research, 2013 , vol. 41, # 13 p. 6774 - 6781
反应条件
1H-imidazole in N,N-dimethyl-formamide
T=25°C;
参考文献
Bartholomae, Mark D.; Vortherms, Anthony R.; Hillier, Shawn; Joyal, John; Babich, John; Doyle, Robert P.; Zubieta, Jon
Dalton Transactions, 2011 , vol. 40, # 23 p. 6216 - 6225
反应条件
1: 2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)-5-iodouridine sodium salt With n-butyllithium in tetrahydrofuran
T=-78°C;
2: methyl iodide in tetrahydrofuran
Further stages.;
参考文献
Aso, Mariko; Kaneko, Toshiyuki; Nakamura, Morihide; Koga, Noboru; Suemune, Hiroshi
Chemical communications (Cambridge, England), 2003 , # 9 p. 1094 - 1095
