2-甲基-2-(3-氧代-丁基)-环己酮合成路线 （共 17 条）
反应条件
boron trifluoride diethyl etherate in diethyl ether; dichloromethane
-70 deg C to -30 deg C;
参考文献
Duhamel, P.; Hennequin, L.; Poirier, J. M.; Tavel, G.; Vottero, C.
Tetrahedron, 1986 , vol. 42, # 17 p. 4777 - 4786
反应条件
oxygen; copper dichloride; palladium dichloride in water; N,N-dimethyl-formamide
T=70°C; 1) 150 min, 2) 1 h;
参考文献
Grattan, T. J.; Whitehurst, J. S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 1 p. 11 - 18
反应条件
(-)-menthol; boron trifluoride diethyl etherate in nitromethane; dichloromethane
T=-20°C; 1 h;
参考文献
Duhamel, Pierre; Hennequin, Laurent; Poirier, Nelly; Poirier, Jean-Marie
Tetrahedron Letters, 1985 , vol. 26, # 50 p. 6201 - 6204
反应条件
boron trifluoride diethyl etherate in dichloromethane
-70 deg C to -30 deg C;
参考文献
Duhamel, Pierre; Poirier, Jean-Marie; Tavel, Gilbert
Tetrahedron Letters, 1984 , vol. 25, # 1 p. 43 - 46
反应条件
bis-(trifluoromethylsulphonyl)amine in dichloromethane
T=20°C; 1 h;
参考文献
Azuma, Takumi; Takemoto, Yoshiji; Takasu, Kiyosei
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 9 p. 1190 - 1193
反应条件
1: H2 / Pd/CaCO3 / ethyl acetate / 3 h / Ambient temperature
2: 97 percent / 1 M H2SO4 / dioxane / 2.5 h / Ambient temperature
View Scheme
参考文献
Collins, David J.; Rutschmann, Suzanne B.
Australian Journal of Chemistry, 1989 , vol. 42, # 9 p. 1447 - 1454
反应条件
1: 1.) KN(SiMe3)2, 2.) BEt3 / Pd(PPh3)4 / 1.) -78 deg C, 3.) THF, 12h, room temp.
2: Hg(OAc)2, 88percent HCOOH / 3 h
View Scheme
参考文献
Negishi, Ei-ichi; Luo, Fen-Tair; Pecora Anthony J.; Silveira, Augustine
Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2427 - 2430
反应条件
1: 2) aqueous sulphuric acid / 1) toluene-p-sulphonic acid / 1) a) temperature raised to 95 deg C, 4 h, b) 95 deg C, 4 h, 2) dioxane, 50 deg C, 2 h
2: 4 percent / oxygen / palladium chloride, copper(II) chloride / dimethylformamide; H2O / 70 °C / 1) 150 min, 2) 1 h
View Scheme
参考文献
Grattan, T. J.; Whitehurst, J. S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 1 p. 11 - 18
反应条件
1: 64 percent / 20percent aqueous oxalic acid / hot
2: 4 percent / oxygen / palladium chloride, copper(II) chloride / dimethylformamide; H2O / 70 °C / 1) 150 min, 2) 1 h
View Scheme
参考文献
Grattan, T. J.; Whitehurst, J. S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 1 p. 11 - 18
反应条件
(-)-menthol; boron trifluoride diethyl etherate in nitromethane
T=-20°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Duhamel, Pierre; Dujardin, Gilles; Hennequin, Laurent; Poirier, Jean-Marie
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 3 p. 387 - 396
