7-羟基-3-甲基-2H-色烯-2-酮合成路线 （共 10 条）
反应条件
1: 1.4 g / I2, HIO4 / ethanol; H2O / 2 h / Ambient temperature 2: 0.9 g / K2CO3 / acetone / 6 h / Heating 3: 0.24 g / various solvent(s) / 6 h / Heating 4: OsO4, KIO4 / ethyl acetate; H2O / 2 h 5: 0.12 g / PPA / 0.5 h / Heating View Scheme
参考文献
Ahluwalia, V. K.; Bhat, K.; Singh, R. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 403 - 404
反应条件
piperidine; propionic acid sodium salt
6 h; Heating;
参考文献
Leonetti, Francesco; Favia, Angelo; Rao, Angela; Aliano, Rosaria; Paluszcak, Anja; Hartmann, Rolf W.; Carotti, Angelo
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6792 - 6803
反应条件
in toluene
T=60°C; Wittig reaction;
参考文献
Gagey, Nathalie; Neveu, Pierre; Benbrahim, Chouaha; Goetz, Bernard; Aujard, Isabelle; Baudin, Jean-Bernard; Jullien, Ludovic
Journal of the American Chemical Society, 2007 , vol. 129, # 32 p. 9986 - 9998
反应条件
in N,N-dimethyl-formamide
7 h; Heating;
参考文献
Xie, Lan; Takeuchi, Yasuo; Cosentino, L. Mark; Lee, Kuo-Hsiung
Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2662 - 2672
参考文献
Teran, Carmen; Santana, Lourdes; Uriarte, Eugenio; Fall, Yagamare; Unelius, Lena; Tolf, Bo-Ragnar
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 24 p. 3567 - 3570
反应条件
T=20°C; RefluxAcidic conditions;
参考文献
Harada, Koichiro; Kubo, Hideki; Tomigahara, Yoshitaka; Nishioka, Kazuhiko; Takahashi, Junya; Momose, Mio; Inoue, Shinichi; Kojima, Atsuyuki
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 272 - 275
参考文献
Cingolani et al.
Gazzetta Chimica Italiana, 1953 , vol. 83, p. 647,651
参考文献
Michael
Chemische Berichte, 1905 , vol. 38, p. 2087
Journal fuer Praktische Chemie (Leipzig), 1905 , vol. <2> 72, p. 538
反应条件
1: propionic acid-anhydride; piperidine
2: aqueous hydriodic acid
View Scheme
参考文献
Cingolani et al.
Gazzetta Chimica Italiana, 1953 , vol. 83, p. 647,651
反应条件
1: 7-hydroxy-3-methyl-2H-chromen-2-one With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.333333 h;
2: methyl iodide With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 5 h;
参考文献
Leonetti, Francesco; Favia, Angelo; Rao, Angela; Aliano, Rosaria; Paluszcak, Anja; Hartmann, Rolf W.; Carotti, Angelo
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6792 - 6803
