2-氰基-2-丙醇-1,1,1,3,3,3-d6合成路线 （共 8 条）
反应条件
1: 2-hydroxy(2H6)-2-methylpropanenitrile With sulfuric acid T=75 - 140°C; 1.5 h; 2: MeOD-d4 With water 4 h; Heating / reflux;
参考文献
Mitsubishi Gas Chemical Company, Inc; TAIYO NIPPON SANSO CORP
Patent: JP2005/82487 A, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
pyridine; thionyl chloride T=20°C; 3 h;
参考文献
Horino, Yoshikazu; Kimura, Masanari; Tanaka, Shuji; Okajima, Toshiya; Tamaru, Yoshinao
Chemistry - A European Journal, 2003 , vol. 9, # 11 p. 2419 - 2438
反应条件
pyridine; thionyl chloride T=90 - 95°C; 3 h;
参考文献
Hodder, Anthony N.; Holland, Kelvyn A.; Rae, Ian D.
Australian Journal of Chemistry, 1986 , vol. 39, # 11 p. 1883 - 1887
反应条件
sulfuric acid; triethylamine
T=0 - 1°C; 4 h;
参考文献
Mitsubishi Gas Chemical Company, Inc; TAIYO NIPPON SANSO CORP
Patent: JP2005/82487 A, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
sulfuric acid
T=0°C; 0.5 h;
参考文献
Horino, Yoshikazu; Kimura, Masanari; Tanaka, Shuji; Okajima, Toshiya; Tamaru, Yoshinao
Chemistry - A European Journal, 2003 , vol. 9, # 11 p. 2419 - 2438
反应条件
sulfuric acid
T=15 - 20°C; 0.333333 h;
参考文献
Hodder, Anthony N.; Holland, Kelvyn A.; Rae, Ian D.
Australian Journal of Chemistry, 1986 , vol. 39, # 11 p. 1883 - 1887
反应条件
1: With zinc(II) iodide
Addition;
2: With hydrogenchloride
Substitution;
参考文献
Peterson, Chris J.; Tsao, Rong; Coats, Joel R.
Pest Management Science, 2000 , vol. 56, # 7 p. 615 - 617
反应条件
sulfuric acid
T=50°C; Hydrolysis; 48 h;
参考文献
Passarella; Martinelli; Passarotti; Valenti
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 3 p. 275 - 279
