反应条件
1: diethyl malonate With sodium hydride in DMF (N,N-dimethyl-formamide) 2: 4-bromo-benzyl bromide in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3874 - 3883