甲基 4-醛基-1H-吡咯-2-甲酸酯合成路线 （共 10 条）
反应条件
aluminium trichloride in dichloromethane
参考文献
Carter, Paul; Fitzjohn, Steven; Halazy, Serge; Magnus, Philip
Journal of the American Chemical Society, 1987 , vol. 109, # 9 p. 2711 - 2717
反应条件
trichlorophosphate Ambient temperature;
参考文献
Schmuck, Carsten
Tetrahedron, 2001 , vol. 57, # 15 p. 3063 - 3067
反应条件
N,N-dimethyl-formamide; trichlorophosphate in dichloromethane T=0 - 20°C; 0.5 h; Heating / reflux;
参考文献
SEPRACOR INC.
Patent: WO2008/89453 A2, 2008 ;
Location in patent: Page/Page column 94-95 ;
反应条件
1: in N,N-dimethyl-formamide T=20°C; 16 h; 2: With sodium hydroxide in water; N,N-dimethyl-formamide T=0°C; pH=7;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/130231 A1, 2009 ;
Location in patent: Page/Page column 60 ;
WO 2009/130231 A1
反应条件
AlCl3 in CH2Cl2:CH3NO2
参考文献
Pang, Yuan-Ping; Park, Jewn Giew; Wang, Shaohua; Vummenthala, Anuradha; Mishra, Rajesh K.; Davis, Jon; Millard, Charles B.; Schmidt, James J.
Patent: US2012/114696 A1, 2012 ;
反应条件
1: potassium carbonate / methanol 2: AlCl3 / CH2Cl2:CH3NO2 View Scheme
参考文献
Pang, Yuan-Ping; Park, Jewn Giew; Wang, Shaohua; Vummenthala, Anuradha; Mishra, Rajesh K.; Davis, Jon; Millard, Charles B.; Schmidt, James J.
Patent: US2012/114696 A1, 2012 ;
反应条件
trichlorophosphate Multistep reaction;
参考文献
Arban, Roberto; Bianchi, Federica; Buson, Alberto; Cremonesi, Susanna; Fabio, Romano Di; Gentile, Gabriella; Micheli, Fabrizio; Pasquarello, Alessandra; Pozzan, Alfonso; Tarsi, Luca; Terreni, Silvia; Tonelli, Federica
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5044 - 5049
反应条件
2: 1.) POCl3 View Scheme
参考文献
Yamano, Kimiaki; Konno, Katsuhiro; Shirahama, Haruhisa
Chemistry Letters, 1991 , # 9 p. 1541 - 1542
反应条件
1: 88 percent / KMnO4 / acetone; H2O / 20 °C 2: 94 percent / TMSCl / 20 °C View Scheme
参考文献
Meyers, Kenneth M.; Mendez-Andino, Jose; Colson, Anny-Odile; Hu, X. Eric; Wos, John A.; Mitchell, Maria C.; Hodge, Karen; Howard, Jeremy; Paris, Jennifer L.; Dowty, Martin E.; Obringer, Cindy M.; Reizes, Ofer
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 657 - 661
反应条件
1: 1.) NaH / 1.) DME, room temperature, 2.) 1 h
2: 1.) NaH / 1.) benzene, reflux, 2.) room temperature
3: 1.) H2, 2.) aq. HCl / 1.) 10percent Pd/C / 1) ethyl acetate, room temperature, atmospheric pressure, 2.) MeOH, reflux
View Scheme
参考文献
Singh, Rajeshwar; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 3 p. 225 - 227
