1-溴-4,4,4-三氟丁烷合成路线 （共 6 条）
反应条件
phosphorus tribromide
参考文献
ICI Americas Inc.
Patent: US4552883 A1, 1985 ;
反应条件
sulfur(IV) fluoride T=115 - 125°C; Steel bomb tube;
参考文献
Oregon Health and Science University; U.S. Department of Veterans Affairs
Patent: US7829578 B1, 2010 ;
Location in patent: Page/Page column 14-15 ;
参考文献
Muller
Journal of Pharmaceutical Sciences, 1986 , vol. 75, # 10 p. 987 - 991
反应条件
potassium carbonate in N-methyl-acetamide
参考文献
US5310745 A1, ;
US5144037 A1, ;
US5221746 A1, ;
反应条件
in dimethyl sulfoxide
T=110°C; 0.5 h;
参考文献
Ashton, Wallace T.; Chang, Linda L.; Flanagan, Kelly L.; Hutchins, Steven M.; Naylor, Elizabeth M.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 17 p. 2808 - 2826
反应条件
in dimethyl sulfoxide
参考文献
Merck and Co., Inc.
Patent: US5411980 A1, 1995 ;
US 5411980 A
