DL-肉碱合成路线 - 魔法化学

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参考文献

Sandoz Ltd.
Patent: US5412137 A1, 1995 ;

参考文献

Hanselmann, Paul; Klegraf, Ellen; Elzner, Stephan; Quittmann, Wilhelm; Fischer, Daniel Friedrich
Patent: US2012/22275 A1, 2012 ;
Location in patent: Page/Page column 10 ;

107-20-0一氯乙醛+463-51-4乙烯酮+75-50-3三甲胺→541-15-1左旋肉碱+406-76-8DL-肉碱

参考文献

Hanselmann, Paul; Klegraf, Ellen; Elzner, Stephan; Quittmann, Wilhelm; Fischer, Daniel Friedrich
Patent: US2012/22275 A1, 2012 ;
Location in patent: Page/Page column 10 ;

→24587-49-34-羟基-2-丁烯酸+541-15-1左旋肉碱+406-76-8DL-肉碱

参考文献

Hanselmann, Paul; Klegraf, Ellen; Elzner, Stephan; Quittmann, Wilhelm; Fischer, Daniel Friedrich
Patent: US2012/22275 A1, 2012 ;
Location in patent: Page/Page column 10 ;

99211-78-6→406-76-8DL-肉碱

参考文献

Jain, Rajendra P; Williams, Robert M
Tetrahedron, 2001 , vol. 57, # 30 p. 6505 - 6509

133039-09-5→406-76-8DL-肉碱

参考文献

Bellamy; Bondoux; Dodey
Tetrahedron Letters, 1990 , vol. 31, # 50 p. 7323 - 7326

32224-01-4→406-76-8DL-肉碱

参考文献

Fuganti, Claudio; Grasselli, Piero
Tetrahedron Letters, 1985 , vol. 26, # 1 p. 101 - 104

7013-07-2(R)-(-)-4-氨基-3-羟基丁酸+74-88-4甲基碘→541-15-1左旋肉碱+406-76-8DL-肉碱

参考文献

Bose, D. Subhas; Fatima, Liyakat; Rajender, Salla
Synthesis, 2006 , # 11 p. 1863 - 1867

461-06-3肉毒碱→541-15-1左旋肉碱+406-76-8DL-肉碱

参考文献

Berthod; Valleix; Tizon; Leonce; Caussignac; Armstrong
Analytical Chemistry, 2001 , vol. 73, # 22 p. 5499 - 5508

461-06-3肉毒碱→406-76-8DL-肉碱

参考文献

Mueller; Strack
Hoppe-Seyler's Zeitschrift fuer physiologische Chemie, 1972 , vol. 353, # 4 p. 618 - 622