5-(氯甲基)-8-羟基喹啉盐酸盐合成路线 （共 9 条）
反应条件
hydrogenchloride in water T=0 - 20°C; 8 h;
参考文献
VARINEL INC; ZURAWSKI JR, Vincent R.; STOUT, David M.; NITZ, Theodore J.
Patent: WO2012/20389 A1, 2012 ;
Location in patent: Page/Page column 22 ;
WO 2012/020389 A1
参考文献
Zinner; Fiedler
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 493,502
反应条件
1: NH4OH 2: NaH / dimethylformamide / 16 h View Scheme
参考文献
Soulounganga; Gerardin; Loubinoux
Synthetic Communications, 2000 , vol. 30, # 11 p. 1927 - 1935
反应条件
in chloroform T=5 - 20°C; 24 h;
参考文献
Yeda Research and Development Co. Ltd.; Technion Research and Development Foundation Ltd.
Patent: US6855711 B1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
in methanol
T=20°C; 4 h;
参考文献
Yeda Research and Development Co. Ltd.; Technion Research and Development Foundation Ltd.
Patent: US6855711 B1, 2005 ;
Location in patent: Page/Page column 10-11 ;
反应条件
sodium hydrogencarbonate
Heating;
参考文献
Chauhan; Kharadi; Patel
Oriental Journal of Chemistry, 2010 , vol. 26, # 4 p. 1431 - 1436
反应条件
triethylamine in dichloromethane
T=20°C; 0.416667 h;
参考文献
Wang, Feng; Peng, Ruogu; Sha, Yaowu
Molecules, 2008 , vol. 13, # 4 p. 922 - 930
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
Peng, Ruogu; Wang, Feng; Sha, Yaowu
Molecules, 2007 , vol. 12, # 5 p. 1191 - 1201
反应条件
in chloroform
T=5 - 20°C; 48 h;
参考文献
Yeda Research and Development Co. Ltd.; Technion Research and Development Foundation Ltd.
Patent: US6855711 B1, 2005 ;
Location in patent: Page/Page column 11 ;
