6-甲基喹啉-2(1h)-酮合成路线 （共 9 条）
反应条件
water; potassium carbonate; p-toluenesulfonyl chloride in chloroform T=20°C; 2 h;
参考文献
TOYAMA CHEMICAL CO., LTD.; TAISHO PHARMACEUTICAL CO., LTD
Patent: EP1900732 A1, 2008 ;
Location in patent: Page/Page column 102 ;
EP 1900732 A1
反应条件
pyridine; aluminium trichloride in dichloromethane
参考文献
Bauer, Stefanie; Ochoa-Puentes, Cristian; Sun, Qiu; Bause, Manuel; Bernhardt, Guenther; Koenig, Burkhard; Buschauer, Armin
ChemMedChem, 2013 , vol. 8, # 11 p. 1773 - 1778
反应条件
AlCl3, aluminium chloride 0.75 h; Neat (no solvent);
参考文献
Cinelli, Maris A.; Li, Huiying; Chreifi, Georges; Martasek, Pavel; Roman, Linda J.; Poulos, Thomas L.; Silverman, Richard B.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1513 - 1530
反应条件
potassium carbonate 15 h; Heating;
参考文献
Inglis, Steven; Jones, Rhiannon; Fritz, Daniel; Stojkoski, Cvetan; Booker, Grant; Pyke, Simon
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 14 p. 2543 - 2557
反应条件
pyridine; aluminium trichloride 1.) CH2Cl2, 0 deg C, 3 h, 2.) 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Warner; Barker; Jackman; Burrows; Roberts; Bishop; O'Connor; Hughes
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2761 - 2768
反应条件
potassium hydroxide; potassium permanganate
参考文献
Tschitschibabin; Kursanowa
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1930 , vol. 62, p. 1211,1214
Chem. Zentralbl., 1931 , vol. 102, # I p. 86
反应条件
trichlorophosphate T=60°C; Inert atmosphere;
参考文献
US2009/247579 A1, ;
Page/Page column 25; 41 ;
反应条件
1: 85 percent / phosphorus oxychloride / 17 h / 60 °C 2: 57 percent / butan-1-ol / 15 h / 110 °C View Scheme
参考文献
Desos, Patrice; Schlewer, Gilbert; Wermuth, Camille Georges
Heterocycles, 1989 , vol. 28, # 2 p. 1085 - 1099
反应条件
in N-methyl-acetamide; mineral oil
参考文献
Imperial Chemical Industries PLC; ICI Pharma
Patent: US5196419 A1, 1993 ;
US 5196419 A
