1-氟-4-苯基乙炔-苯合成路线 （共 39 条）
反应条件
sodium hydroxide; sodium tetrahydroborate 1.) AcOH, RT, 2.) MeOH, 0 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ballico, Enrico; Floris, Barbara; Giordano, Federico
Journal of Chemical Research, Miniprint, 1996 , # 2 p. 689 - 697
反应条件
palladium dichloride in chlorobenzene 4 h; Reflux; Overall yield = 90 percent;
参考文献
Xie, Hou-Zhi; Gao, Qi; Liang, Ying; Wang, Heng-Shan; Pan, Ying-Ming
Green Chemistry, 2014 , vol. 16, # 4 p. 2132 - 2135
反应条件
bis(η3-allyl-μ-chloropalladium(II)); 1,2-bis(diphenylphosphino)-1'-(diisopropylphosphino)-4-tert-butylferrocene; potassium carbonate; copper(l) iodide in N,N-dimethyl-formamide
T=130°C; Sonogashira cross-coupling reaction; 20 h;
参考文献
Hierso, Jean-Cyrille; Fihri, Aziz; Amardeil, Regine; Meunier, Philippe; Doucet, Henri; Santelli, Maurice; Ivanov, Vladimir V.
Organic Letters, 2004 , vol. 6, # 20 p. 3473 - 3476
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran
T=60°C;
参考文献
Rubin, Michael; Trofimov, Alexander; Gevorgyan, Vladimir
Journal of the American Chemical Society, 2005 , vol. 127, # 29 p. 10243 - 10249
反应条件
[Fe(II)(C5H5)(C5H4PPh2)]; gold monoiodide; potassium carbonate in toluene
T=130°C; Sonogashira reaction; 24 h;
参考文献
Li, Pinhua; Wang, Lei; Wang, Min; You, Feng
European Journal of Organic Chemistry, 2008 , # 35 p. 5946 - 5951
反应条件
copper(l) iodide; potassium carbonate; triphenylphosphine in dimethyl sulfoxide
T=90°C; 24 h; Inert atmosphere;
参考文献
Li, Tingyi; Sun, Peng; Yang, Hailong; Zhu, Yan; Yan, Hong; Lu, Linhua; Mao, Jincheng
Tetrahedron, 2012 , vol. 68, # 32 p. 6413 - 6419
反应条件
copper(l) iodide; 8-hydroxy-quinoline; sodium salt of phosphorous acid in ethanol
T=80°C; Suzuki coupling; 24 h;
参考文献
Zhang, Xiuli; Li, Pinhua; Ji, Yong; Zhang, Lei; Wang, Lei
Synthesis, 2011 , # 18 art. no. H38111SS, p. 2975 - 2983
反应条件
potassium acetate; palladium diacetate; silver(l) oxide in dichloromethane
T=20°C; 12 h; Molecular sieve;
参考文献
Feng, Chao; Loh, Teck-Peng
Chemical Communications, 2010 , vol. 46, # 26 p. 4779 - 4781
反应条件
potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); Tedicyp in N,N-dimethyl-formamide
T=140°C; Sonogashira cross-coupling; 20 h;
参考文献
Feuerstein, Marie; Doucet, Henri; Santelli, Maurice
Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8443 - 8446
反应条件
copper(l) iodide; potassium carbonate; triphenylphosphine in dimethyl sulfoxide
T=100°C; 24 h; Inert atmosphere;
参考文献
Li, Tingyi; Sun, Peng; Yang, Hailong; Zhu, Yan; Yan, Hong; Lu, Linhua; Mao, Jincheng
Tetrahedron, 2012 , vol. 68, # 32 p. 6413 - 6419
