1: 78 percent / trimethylsilyl chloride / CHCl3 / 1 h / Ambient temperature 2: 1.) lithium 4,4'-di-tert-butylbiphenylide / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C to room temp. 3: 1.) n-BuLi, lithium 4,4'-di-tert-butylbiphenylide, 2.) MeOH / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C View Scheme

1: 1.) lithium 4,4'-di-tert-butylbiphenylide / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C to room temp. 2: 1.) n-BuLi, lithium 4,4'-di-tert-butylbiphenylide, 2.) MeOH / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C View Scheme

ethanol; sodium

(i) Al, HgCl2, ZnCl2, MeI, (ii) /BRN= 605308/, CuBr2; Multistep reaction;

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