反应条件
1: 6-bromo-2-methoxypyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 4 h; Inert atmosphere; 2: ethyl acetate With water T=20°C; pH=4; Inert atmosphere;
参考文献
Casimiro-Garcia, Agustin; Piotrowski, David W.; Ambler, Catherine; Arhancet, Graciela B.; Banker, Mary Ellen; Banks, Tereece; Boustany-Kari, Carine M.; Cai, Cuiman; Chen, Xiangyang; Eudy, Rena; Hepworth, David; Hulford, Catherine A.; Jennings, Sandra M.; Loria, Paula M.; Meyers, Marvin J.; Petersen, Donna N.; Raheja, Neil K.; Sammons, Matthew; She, Li; Song, Kun; Vrieze, Derek; Wei, Liuqing
Journal of Medicinal Chemistry, 2014 , vol. 57, # 10 p. 4273 - 4288