2-(噻吩-2-基)乙基对甲苯磺酸酯合成路线

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参考文献

Sajja, Eswaraiah; Anumula, Raghupathi Reddy; Gilla, Goverdhan; Madivada, Lokeswara Rao
Patent: US2007/225320 A1, 2007 ;
Location in patent: Page/Page column 5 ;

7732-18-5水+

98-59-9对甲苯磺酰氯

→

40412-06-42-(噻吩-2-基)乙基对甲苯磺酸酯

参考文献

G. D. Searle and Co.
Patent: US4822775 A1, 1989 ;

5402-55-1噻吩乙醇+

104-15-4对甲苯磺酸

→

40412-06-42-(噻吩-2-基)乙基对甲苯磺酸酯

参考文献

Ferraboschi, Patrizia; Mieri, Maria De; Galimberti, Fiorella
Tetrahedron Asymmetry, 2010 , vol. 21, # 17 p. 2136 - 2141

40412-06-42-(噻吩-2-基)乙基对甲苯磺酸酯+

78950-82-0外消旋-5,6,7,8-四氢-6-(丙基氨基)-1-萘酚

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92206-54-7罗替戈汀

参考文献

SHAN DONG LUYE PHARMACEUTICAL CO., LTD.; Meng, Qingguo; Yang, Mina; Wang, Tao; Wang, Qilin; Li, Jun; Ruan, Zheng
Patent: US2014/121380 A1, 2014 ;
Location in patent: Paragraph 0059 ;

40412-06-42-(噻吩-2-基)乙基对甲苯磺酸酯+

101470-23-9(-)-(6-丙基氨基)-5,6,7,8-四氢-萘-1-醇

→

99755-59-6罗替戈汀

参考文献

Organic Letters, , vol. 12, # 23 p. 5418 - 5421

40412-06-42-(噻吩-2-基)乙基对甲苯磺酸酯

→

99755-59-6罗替戈汀

参考文献

US2013/102794 A1, ;

Paragraph 0257-0260 ;

40412-06-42-(噻吩-2-基)乙基对甲苯磺酸酯+

101470-23-9(-)-(6-丙基氨基)-5,6,7,8-四氢-萘-1-醇

→

1148007-88-8+

99755-59-6罗替戈汀

参考文献

WO2009/53697 A1, ;

Page/Page column 14; 15 ;

40412-06-42-(噻吩-2-基)乙基对甲苯磺酸酯+

213018-92-9L-(+)-2-氯苯甘氨酸甲酯盐酸盐

→

113665-84-2氯吡格雷

参考文献

HANMI PHARM. CO., LTD.
Patent: WO2005/87779 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;

40412-06-42-(噻吩-2-基)乙基对甲苯磺酸酯

→

113665-84-2氯吡格雷

参考文献

ORCHID CHEMICALS AND PHARMACEUTICALS LTD; RAO, Jagadeeshwar; NANDAM, Harikrishna; REDAMALLA, Anjireddy; REGURI, Buchi, Reddy
Patent: WO2011/12961 A1, 2011 ;

40412-06-42-(噻吩-2-基)乙基对甲苯磺酸酯

→

125572-93-2盐酸罗替戈汀

参考文献

UCB PHARMA GMBH; ATES, Celal; SCHULE, Arnaud; PALACIO, Magali; DEUTSCH, Paul; VASSELIN, David; CARLY, Nicolas; PHADTARE, Ganesh; YERANDE, Swapnil; DELATINNE, Jean-Pierre; ESCUDERO HERNANDEZ, Maria Luisa; PINILLA, Veronique
Patent: WO2011/161255 A2, 2011 ;
Location in patent: Page/Page column 36-37 ;