3-羟基-4-甲基戊酸乙酯合成路线 （共 13 条）
反应条件
1: POCl3 / pyridine 2: KOH (40percent) / H2O; ethanol / 48 h / Heating View Scheme
参考文献
Bigley, David B.; Fetter, Clive L.; Clarke, Michael J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 553 - 556
反应条件
1: POCl3 / pyridine 2: KOH (40percent) / H2O; ethanol / 48 h / Heating View Scheme
参考文献
Bigley, David B.; Fetter, Clive L.; Clarke, Michael J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 553 - 556
反应条件
boron trifluoride diethyl etherate; water; zinc in tetrahydrofuran
T=20°C; Addition; Reformatsky reaction;
参考文献
Chattopadhyay, Angshuman; Salaskar, Avinash
Synthesis, 2000 , # 4 p. 561 - 564
反应条件
manganese; bis(cyclopentadienyl)titanium dichloride in tetrahydrofuran
T=20°C; Reformatsky-like addition; 6 h;
参考文献
Parrish; Shelton, Daniel R.; Little, R. Daniel
Organic Letters, 2003 , vol. 5, # 20 p. 3615 - 3617
反应条件
manganese; bis(cyclopentadienyl)titanium dichloride in tetrahydrofuran
T=20°C; Reformatsky-like addition; 1 h;
参考文献
Parrish; Shelton, Daniel R.; Little, R. Daniel
Organic Letters, 2003 , vol. 5, # 20 p. 3615 - 3617
反应条件
hydrogen; palladium on activated charcoal in methanol
P=3040 Torr; 1 h; Ambient temperature;
参考文献
Pellicciari, Roberto; Natalini, Benedetto; Cecchetti, Sergio; Fringuelli, Renata
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 493 - 498
反应条件
n-butyllithium; 1,1-Bis(trimethylsilyl)-3-methylbutanol-(1) in tetrahydrofuran
参考文献
Kuwajima,I. et al.
Tetrahedron Letters, 1976 , p. 2253 - 2256
反应条件
titanium tetrachloride in dichloromethane
0.166667 h; Ambient temperature;
参考文献
Kiyooka, Syun-ichi; Nakata, Masumi
Chemistry Letters, 1988 , p. 721 - 722
反应条件
sodium tetrahydroborate
T=20°C; 0.5 h;
参考文献
Kim, Juryoung; De Castro, Kathlia A.; Lim, Minkyung; Rhee, Hakjune
Tetrahedron, 2010 , vol. 66, # 23 p. 3995 - 4001
反应条件
tert.-butyl lithium; sodium carbonate
1.) Et2O, pentane, -78 deg C, 90 min; 2.) Et2O, pentane, -30 deg C, 75 min; 3.) Et2O, pentane, H2O, r.t., 30 min; Yield given. Multistep reaction;
参考文献
Hiouni, Abdelaziz; Duhamel, Lucette
Tetrahedron Letters, 1996 , vol. 37, # 31 p. 5507 - 5510
