2-羟基-3,3-二甲基丁酸合成路线 （共 34 条）
反应条件
sodium hydroxide; oxygen; platinum on activated charcoal
T=70°C; 5 h;
参考文献
Tuck, Kellie L.; Saldanha, S. Adrian; Birch, Louise M.; Smith, Alison G.; Abell, Chris
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 19 p. 3598 - 3610
反应条件
(i) KMnO4, (ii) H2, Raney-Ni; Multistep reaction;
参考文献
Tanabe,T. et al.
Bulletin of the Chemical Society of Japan, 1968 , vol. 41, p. 2178 - 2179
反应条件
3-chloro-benzenecarboperoxoic acid in hexane
参考文献
Rubottom,G.M.; Marrero,R.
Journal of Organic Chemistry, 1975 , vol. 40, p. 3783 - 3784
反应条件
zinc(II) chloride in dichloromethane
Ambient temperature;
参考文献
Reetz, Manfred T.; Heimbach, Horst
Chemische Berichte, 1983 , vol. 116, # 11 p. 3702 - 3707
反应条件
1: (i) LDA, THF, (ii) /BRN= 1209232/
2: O2, tetraphenylporphyrin / Irradiation
3: MeOH
4: (reduction)
View Scheme
参考文献
Adam,W. et al.
Journal of the American Chemical Society, 1977 , vol. 99, # 17 p. 5768 - 5773
反应条件
1: MeOH
2: (reduction)
View Scheme
参考文献
Adam,W. et al.
Journal of the American Chemical Society, 1977 , vol. 99, # 17 p. 5768 - 5773
反应条件
sodium methylate in methanol
1 h; electrolysis;
参考文献
Rabjohn, Norman; Cranor, W. L.; Schofield, C. M.
Journal of Organic Chemistry, 1984 , vol. 49, # 10 p. 1732 - 1736
反应条件
1: 79 percent / triethylamine / tetrahydrofuran / 2 h / 20 °C
2: 93 percent / cc. aq. HCl / 24 h / Heating
View Scheme
参考文献
Mizuno, Masanori; Shioiri, Takayuki
Tetrahedron Letters, 1998 , vol. 39, # 50 p. 9209 - 9210
反应条件
alkaline copper
T=75 - 90°C;
参考文献
Faworski
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1912 , vol. 44, p. 1370
Journal fuer Praktische Chemie (Leipzig), 1913 , vol. <2> 88, p. 672
参考文献
Adam,W. et al.
Journal of the American Chemical Society, 1977 , vol. 99, # 17 p. 5768 - 5773
