1-(4-氯苯基)双胍 盐酸盐合成路线 （共 11 条）
反应条件
hydrogenchloride in 1,4-dioxane; water T=90°C; 0.25 h; Microwave irradiation;
参考文献
Chen, Huixiong; Dao, Pascal; Laporte, Alice; Garbay, Christiane
Tetrahedron Letters, 2010 , vol. 51, # 24 p. 3174 - 3176
参考文献
Clauder; Bulcsu
Magyar Kemiai Folyoirat, 1951 , vol. 57, p. 68,71
Chem.Abstr., 1952 , p. 4023
Full Text Show Details
Heumann and Co.
Patent: DE1008303 , 1955 ;
参考文献
Loo
Journal of the American Chemical Society, 1954 , vol. 76, p. 5096,5098
Full Text Show Details
Bami; Modest; Levine
Journal of Organic Chemistry, 1956 , vol. 21, p. 14,19
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Carrington et al.
Journal of the Chemical Society, 1954 , p. 1017,1026
反应条件
1: N1-(p-Chlorophenyl)biguanide hydrochloride With sodium methylate in methanol T=20°C; 3 h; 2: chloroacetic acid ethyl ester in methanol T=20°C; Reflux;
参考文献
Ma, Xiang; Poon, Thong-Yuen; Wong, Peter Tsun Hon; Chui, Wai-Keung
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 19 p. 5644 - 5647
反应条件
sodium acetate; acetic acid
参考文献
Cliffe et al.
Journal of the Chemical Society, 1948 , p. 574,578
参考文献
Carrington et al.
Journal of the Chemical Society, 1954 , p. 1017,1026
Full Text Show Details
Modest; Levine
Journal of Organic Chemistry, 1956 , vol. 21, p. 14,16
反应条件
hydrogenchloride; 1,1,1-triethoxyethane in methanol T=20°C;
参考文献
Saesaengseerung, Neungruthai; Vilaivan, Tirayut; Thebtaranonth, Yodhathai
Synthetic Communications, 2002 , vol. 32, # 14 p. 2089 - 2100
反应条件
1,4-dioxane; sodium hydroxide
参考文献
Birtwell
Journal of the Chemical Society, 1949 , p. 2561,2568
反应条件
1: N1-(p-Chlorophenyl)biguanide hydrochloride With sodium methylate in methanol
T=20°C; 3 h;
2: ethyl acetate in methanol
T=20°C; Reflux;
参考文献
Ma, Xiang; Poon, Thong-Yuen; Wong, Peter Tsun Hon; Chui, Wai-Keung
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 19 p. 5644 - 5647
反应条件
1,4-dioxane; sodium hydroxide
参考文献
Curd; Rose
Journal of the Chemical Society, 1946 , p. 362,365
