3,4-二甲氧基苯乙基溴合成路线 （共 22 条）
反应条件
1: ammonia / ethanol; water / 4 h / 20 °C 2: triethylamine / acetonitrile / 4 h / 20 °C View Scheme
参考文献
Kiruthika, Selvarangam E.; Perumal, Paramasivan Thirumalai
Organic Letters, 2014 , vol. 16, # 2 p. 484 - 487
参考文献
Kanaoka
Chemical and Pharmaceutical Bulletin, 1959 , vol. 7, p. 597,600
反应条件
hydrogenchloride; sodium hydroxide
参考文献
Eli Lilly and Company
Patent: US3987200 A1, 1976 ;
反应条件
1: 1-(1-phenylethyl)-1,2,3,4-tetrahydroquinoline-2-carbonitrile With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78 - -20°C; Inert atmosphere; 2: 1-bromo-2-(3,4-dimethoxyphenyl)ethane in tetrahydrofuran; 1,1,2,3,4,4-hexachloro-1,3-butadiene T=-60 - 20°C; 12 h;
参考文献
Shahane, Saurabh; Louafi, Fadila; Moreau, Julie; Hurvois, Jean-Pierre; Renaud, Jean-Luc; Van De Weghe, Pierre; Roisnel, Thierry
European Journal of Organic Chemistry, 2008 , # 27 p. 4622 - 4631
反应条件
potassium carbonate in acetonitrile 48 h; Heating;
参考文献
Tetrahedron: Asymmetry, , vol. 1, # 1 p. 33 - 56
反应条件
sodium hydrogencarbonate; sodium iodide in ethanol 60 h; Heating;
参考文献
Coote, Steven J.; Davies, Stephen G.; Middlemiss, David; Naylor, Alan
Tetrahedron: Asymmetry, 1990 , vol. 1, # 1 p. 33 - 56
反应条件
1: pyrrole With potassium hydroxide; 18-crown-6 ether in benzene 2 h; Heating; 2: 1-bromo-2-(3,4-dimethoxyphenyl)ethane in benzene Heating; Further stages.;
参考文献
Australian Journal of Chemistry, , vol. 61, # 2 p. 80 - 93
反应条件
sodium hydride 1) benzene, reflux, 4 h 2) benzene, reflux, 16 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Matoba; Imai; Nishino; et al.
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 6 p. 1810 - 1813
反应条件
ammonia in ethanol; water T=20°C; 4 h;
参考文献
Organic Letters, , vol. 16, # 2 p. 484 - 487
参考文献
Sugasawa; Kakemi
Chemische Berichte, 1939 , vol. 72, p. 980,983
Yakugaku Zasshi, 1940 , vol. 60, p. 6,9, 10
