3-氨基-4-羟基吡啶盐酸盐合成路线 （共 4 条）
反应条件
chloro-trimethyl-silane T=20°C; 16 h;
参考文献
WO2008/29370 A1, ;
Page/Page column 31; 32 ;
反应条件
thionyl chloride in ethanol
反应条件
1: With sodium hydroxide in tetrahydrofuran; methanol; water T=20°C; 0.5 h; 2: With hydrogenchloride in water
参考文献
XENON PHARMACEUTICALS INC.; GENENTECH, INC; Chowdhury, Sultan; Dehnhardt, Christoph Martin; Focken, Thilo; Grimwood, Michael Edward; Hemeon, Ivan William; Jia, Qi; Ortwine, Daniel; Safina, Brian; Sun, Shaoyi; Sutherlin, Daniel P.; Zenova, Alla Yurevna
Patent: US2013/317000 A1, 2013 ;
Location in patent: Paragraph 0368-0369 ;
反应条件
triethylamine in ethanol
T=120°C; 0.166667 h; Microwave irradiation;
参考文献
Bach, Peter; Bostroem, Jonas; Brickmann, Kay; Van Giezen; Hovland, Ragnar; Petersson, Annika U.; Ray, Asim; Zetterberg, Fredrik
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2877 - 2881
