(1-苄基哌啶-4-基)乙酸乙酯合成路线 （共 20 条）
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran; mineral oil T=20°C; Cooling with ice; 2: 1-Phenylmethyl-piperidin-4-one in tetrahydrofuran; mineral oil T=20°C; 0.5 h; Cooling with iceInert atmosphere;
参考文献
SK CHEMICALS CO., LTD.; KIM, Seon-Mi; KIM, Jae-Sun; LEE, Minhee; LEE, So-Young; LEE, Bong-Yong; SHIN, Young Ah; PARK, Euisun; LEE, Jung A; HAN, Min-Young; AHN, Jaeseung; YOO, Taekyung; KIM, Hun-Taek
Patent: WO2013/129879 A1, 2013 ;
Location in patent: Page/Page column 35 ;
反应条件
1: (MeO)2P(O)CH2CO2Et With sodium hydride in tetrahydrofuran 0.666667 h; 2: 1-Phenylmethyl-piperidin-4-one in tetrahydrofuran T=20°C; 1.33333 h;
参考文献
METHYLGENE INC.
Patent: WO2007/118137 A1, 2007 ;
Location in patent: Page/Page column 127-128 ;
反应条件
1: With trifluoromethylsulfonic anhydride in dichloromethane T=20°C; 0.0833333 h; 2: With diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate in dichloromethane T=20°C; 1 h; Further stages.;
参考文献
Barbe, Guillaume; Charette, Andre B.
Journal of the American Chemical Society, 2008 , vol. 130, # 1 p. 18 - 19
反应条件
in toluene Wittig reaction;
参考文献
Kordik, Cheryl P.; Luo, Chi; Gutherman, Maryann; Vaidya, Anil H.; Rosenthal, Daniel I.; Crooke, Jeffrey J.; McKenney, Sandra L.; Plata-Salaman, Carlos R.; Reitz, Allen B.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 3065 - 3067
反应条件
NaH in tetrahydrofuran; water
参考文献
Les Laboratoires Meram
Patent: US4983614 A1, 1991 ;
反应条件
in ethylene glycol dimethyl ether
参考文献
Pfizer Inc.
Patent: US4289772 A1, 1981 ;
US 4289772 A
反应条件
1: potassium carbonate / dimethylformamide / 70 °C 2: aq.HCl / benzene / 24 h / Heating 3: 1.) NaH / 1.)a) THF, RT, 10 min, b) reflux, 15 min, 2.) THF, reflux, 1.5 h View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1: potassium carbonate / dimethylformamide / 70 °C 2: aq.HCl / benzene / 24 h / Heating 3: 1.) NaH / 1.)a) THF, RT, 10 min, b) reflux, 15 min, 2.) THF, reflux, 1.5 h View Scheme
参考文献
Dutta; Xu; Reith
Journal of Medicinal Chemistry, 1996 , vol. 39, # 3 p. 749 - 756
反应条件
1: aq.HCl / benzene / 24 h / Heating 2: 1.) NaH / 1.)a) THF, RT, 10 min, b) reflux, 15 min, 2.) THF, reflux, 1.5 h View Scheme
参考文献
Dutta; Xu; Reith
Journal of Medicinal Chemistry, 1996 , vol. 39, # 3 p. 749 - 756
反应条件
sodium hydride in ethylene glycol dimethyl ether T=30°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Gupta; Saxena; Jain; Anand
Archiv der Pharmazie, 1984 , vol. 317, # 12 p. 1010 - 1017
