4-氨基-3-硝基三氟甲苯合成路线 （共 50 条）
反应条件
1: With hydrogenchloride; sodium nitrite T=0°C; 0.75 h; 2: With sulfur dioxide; acetic acid; copper dichloride 1.5 h;
参考文献
Lebegue, Nicolas; Gallet, Sebastien; Flouquet, Nathalie; Carato, Pascal; Pfeiffer, Bruno; Renard, Pierre; Leonce, Stephane; Pierre, Alain; Chavatte, Philippe; Berthelot, Pascal
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7363 - 7373
反应条件
1: 82 percent / AcOH / 5 h / Heating 2: 90 percent / H2 / 5 percent Pd/C / methanol View Scheme
参考文献
Kaiya; Fujiwara; Kohda
Chemical Research in Toxicology, 2000 , vol. 13, # 10 p. 993 - 1001
反应条件
hydrogenchloride; sodium nitrite in water
参考文献
SmithKline Corporation
Patent: US28939 E1, 1976 ;
反应条件
sodium nitrite 1.) glacial acetic acid, concd. sulfuric acid, 10 to 20 deg C; Yield given. Multistep reaction;
参考文献
Barlin, Gordon B.; Jiravinyu, Chuenjit
Australian Journal of Chemistry, 1990 , vol. 43, # 2 p. 311 - 319
反应条件
(i) NaNO2, H2SO4, (ii) aq. ZnCl2, (iii) /BRN= 3587243/, CuCN, aq. NaHCO3; Multistep reaction;
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
1: (i) NaNO2, H2SO4, (ii) aq. ZnCl2, (iii) /BRN= 3587243/, CuCN, aq. NaHCO3 2: H2 / Raney-Ni / methanol View Scheme
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
1: 1.) NaNO2, sulfuric acid; 2.) KSCN / 1.) water, 0-5 deg C, 90 min; 2.) water, 3 deg C, 2 h; water, 70 deg C, 20 min 2: Sn, conc. HCl / 20 h View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 83, # 10 p. 1425 - 1432
反应条件
in acetone 50 h; Heating; Yield given;
参考文献
Walchshofer; Delabre-Defayolle; Paris; Petavy
Journal of Pharmaceutical Sciences, 1990 , vol. 79, # 7 p. 606 - 608
反应条件
1: 1.) HNO2 2: 100 percent / SnCl2, conc. HCl / ethanol / 2 h / 100 °C View Scheme
参考文献
Shigyo; Sato; Shibuya; Takahashi; Yamaguchi; Sonoki; Ohta
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 9 p. 1573 - 1582
反应条件
1: 1.) NaNO2, conc. aq. HCl / 1.) H2O, 30 min, 2.) H2O, 1.5 h 2: aq. HCl / Heating View Scheme
参考文献
Wani; Nicholas; Manikumar; Wall
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1774 - 1779
