5-羟基甲基-吡啶-2-羧酸合成路线 （共 7 条）
反应条件
1: With lithium borohydride in tetrahydrofuran
T=0 - 20°C; 2 h;
2: With hydrogenchloride in tetrahydrofuran; water
T=0°C;
参考文献
Galley, Guido; Kitas, Eric Argirios; Jakob-Roetne, Roland
Patent: US2006/14945 A1, 2006 ;
Location in patent: Page/Page column 40 ;
反应条件
dihydrogen peroxide in water
16 h; Ambient temperature;
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
1: 67 percent / conc. H2SO4 / 16 h / Heating
2: 51 percent / NaBH4, CaCl2 / ethanol / 16 h / Ambient temperature
3: 59 percent / SeO2, H2O / dioxane / 3 h / 100 °C
4: 97 percent / 30percent H2O2 / H2O / 16 h / Ambient temperature
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
1: 59 percent / SeO2, H2O / dioxane / 3 h / 100 °C
2: 97 percent / 30percent H2O2 / H2O / 16 h / Ambient temperature
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
1: 51 percent / NaBH4, CaCl2 / ethanol / 16 h / Ambient temperature
2: 59 percent / SeO2, H2O / dioxane / 3 h / 100 °C
3: 97 percent / 30percent H2O2 / H2O / 16 h / Ambient temperature
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
sulfuric acid; triethylamine; calcium chloride
1.) EtOH, 2.) reflux, 4 h; Yield given. Multistep reaction;
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
1: 1.) Et3N, CaCl2, 2.) H2SO4 / 1.) EtOH, 2.) reflux, 4 h
2: 59 percent / CrO3, pyridine / CH2Cl2 / 4 h / Ambient temperature
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
