1: With triphenylphosphine in tetrahydrofuran T=0 - 20°C; 16 h; 2: With ammonium hydroxide in tetrahydrofuran 3 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2006/25433 A1, 2006 ;
Location in patent: Page/Page column 107 ;
US 20060025433 A1
1: Diazotization.Behandlung der Diazoniumsulfatloesung mit Jodwasserstoffsaeure 2: bromine / 200 °C / man destilliert das Produkt im Dampf von konz. Bromwasserstoffsaeure 3: alcohol; ammonia View Scheme
参考文献
Mabery; Robinson
American Chemical Journal, 1882 , vol. 4, p. 101