4-氟-1,2-二甲氧基苯合成路线 （共 20 条）
反应条件
1: With hydrogenchloride; hydrofluoroboric acid; sodium nitrite in water T=25°C; Balz-Schiemann Reaction; 0.00277778 h; 2: in chlorobenzene T=130°C; Balz-Schiemann Reaction; 0.0166667 h;
参考文献
Yu, Zhi-Qun; Lv, Yan-Wen; Yu, Chuan-Ming; Su, Wei-Ke
Tetrahedron Letters, 2013 , vol. 54, # 10 p. 1261 - 1263
反应条件
1.1: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C 1.2: 0.5 h 2.1: Cu(OTf)2; potassium fluoride; 18-crown-6 ether / N,N-dimethyl-formamide / 18 h / 60 °C View Scheme
参考文献
Ichiishi, Naoko; Canty, Allan J.; Yates, Brian F.; Sanford, Melanie S.
Organic Letters, 2013 , vol. 15, # 19 p. 5134 - 5137
反应条件
1: With tetrakis(triphenylphosphine) palladium(0); hexamethyl-distannane in 1,4-dioxane T=105°C; 16 h; Inert atmosphere; 2: With silver trifluoromethanesulfonate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetone T=20°C; 0.333333 h;
参考文献
Teare, Harriet; Robins, Edward G.; Kirjavainen, Anna; Forsback, Sarita; Sandford, Graham; Solin, Olof; Luthra, Sajinder K.; Gouverneur, Veronique
Angewandte Chemie - International Edition, 2010 , vol. 49, # 38 p. 6821 - 6824
反应条件
lt;(η-C6H6)(η-C5EtMe4)Rhgt;(2+)*lt;PF6(1-)gt;2 in nitromethane T=80°C; 96 h;
参考文献
Goryunov, L. I.; Litvak, V. V.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 6 p. 1112 - 1118
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 6 p. 1230 - 1237
反应条件
1: caesium carbonate / acetonitrile / 0.5 h / 60 °C / |Inert atmosphere 2: 18-crown-6 ether; TBAF(tert-BuOH)4 / acetonitrile / 1 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Ikawa, Takashi; Masuda, Shigeaki; Nishiyama, Tsuyoshi; Takagi, Akira; Akai, Shuji
Australian Journal of Chemistry, 2014 , vol. 67, # 3 p. 475 - 480
反应条件
1: caesium carbonate / acetonitrile / 0.5 h / 60 °C / |Inert atmosphere 2: TBAF(tert-BuOH)4 / acetonitrile / 1 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Ikawa, Takashi; Masuda, Shigeaki; Nishiyama, Tsuyoshi; Takagi, Akira; Akai, Shuji
Australian Journal of Chemistry, 2014 , vol. 67, # 3 p. 475 - 480
反应条件
boron tribromide in dichloromethane T=-80 - 20°C; 13 h;
参考文献
Saito, Shizuka; Kawabata, Jun
Tetrahedron, 2005 , vol. 61, # 34 p. 8101 - 8108
反应条件
potassium hexamethylsilazane in tetrahydrofuran T=80°C; Substitution; 4 h;
参考文献
Caron, Stephane; Vazquez, Enrique; Wojcik, Jill M.
Journal of the American Chemical Society, 2000 , vol. 122, # 4 p. 712 - 713
反应条件
titanium tetrachloride in dichloromethane 0 deg C, 0.5 h; RT, 4.5 h;
参考文献
Adejare, Adeboye; Gusovsky, Fabian; Padgett, William; Creveling, Cyrus R.; Daly, John W.; Kirk, Kenneth L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 1972 - 1977
参考文献
Pfizer Inc.
Patent: US6677378 B2, 2004 ;
