4-(氯甲基)苯基乙酸酯合成路线 （共 11 条）
反应条件
sodium perborate in methanol T=25°C; 0.5 h;
参考文献
Bandgar, Babasaheb P.; Uppalla, Lavkumar S.; Sadavarte, Vaibhav S.; Patil, Suresh V.
New Journal of Chemistry, 2002 , vol. 26, # 10 p. 1273 - 1276
反应条件
sodium iodide in butanone 18 h; Ambient temperature;
参考文献
Muto; Kuroda; Kawato; Nishikawa; Nakamizo
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 11 A p. 1666 - 1670
反应条件
sulfuric acid in methanol 48 h; Ambient temperature;
参考文献
Dimmel, Donald R.; Shepard, Donaline
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 22 - 29
反应条件
palladium diacetate; tris(4-methylphenyl)-phosphine in toluene T=20°C; 2 h; Inert atmosphere;
参考文献
Chen, Chi-Ren; Zhou, Shuangliu; Biradar, Deepak Baburao; Gau, Han-Mou
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 10 p. 1718 - 1727
反应条件
2,4,6-trichloro-1,3,5-triazine; dimethyl sulfoxide
T=20°C; 0.333333 h; chemoselective reaction;
参考文献
Sun, Lili; Peng, Guisheng; Niu, Hongmei; Wang, Qiang; Li, Chunbao
Synthesis, 2008 , # 24 art. no. F17308SS, p. 3919 - 3924
反应条件
1: 89 percent / NaBH4 / tetrahydrofuran / 1.5 h / 0 °C
2: SOCl2; pyridine / toluene / 1 h / Heating
View Scheme
参考文献
Hulsman, Niels; Medema, Jan Paul; Bos, Carina; Jongejan, Aldo; Leurs, Rob; Smit, Martine J.; De Esch, Iwan J. P.; Richel, Dick; Wijtmans, Maikel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2424 - 2431
反应条件
2,2'-azo-bisisobutyronitrile; sodium acetate; acetic anhydride; chlorine
参考文献
Eastman Kodak Company
Patent: US4342877 A1, 1982 ;
反应条件
Ambient temperature; Yield given;
参考文献
Christensen, Joern B.
Organic Preparations and Procedures International, 1994 , vol. 26, # 4 p. 471 - 472
反应条件
1: 71 percent / Et3N / tetrahydrofuran / 20 °C
2: 89 percent / NaBH4 / tetrahydrofuran / 1.5 h / 0 °C
3: SOCl2; pyridine / toluene / 1 h / Heating
View Scheme
参考文献
Hulsman, Niels; Medema, Jan Paul; Bos, Carina; Jongejan, Aldo; Leurs, Rob; Smit, Martine J.; De Esch, Iwan J. P.; Richel, Dick; Wijtmans, Maikel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2424 - 2431
反应条件
palladium diacetate; tris(4-methylphenyl)-phosphine in toluene
T=20°C; 2 h; Inert atmosphere;
参考文献
Chen, Chi-Ren; Zhou, Shuangliu; Biradar, Deepak Baburao; Gau, Han-Mou
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 10 p. 1718 - 1727
