1-(4-甲基苯基)哌嗪合成路线 （共 31 条）
反应条件
(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran; toluene T=80 - 90°C; 48 h;
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh; Shen, Lan; Anderson Evans; Goodman, Andrew
Tetrahedron Letters, 2002 , vol. 43, # 18 p. 3359 - 3363
反应条件
1: piperazine With [2,2']bipyridinyl; 1,1-dimethylpropan-1-ol; nickel diacetate in tetrahydrofuran T=63°C; complex formation; 2 h; 2: 4-methyl-chlorobenzene With styrene in tetrahydrofuran Arylation; 6.5 h; Heating;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2881 - 2884
反应条件
potassium tert-butylate; bis(1,3-di-tert-butylimidazolin-2-ylidene)palladium(0) in 1,4-dioxane T=100°C; 16 h;
参考文献
Caddick, Stephen; Cloke, F. Geoffrey N.; Clentsmith, Guy K.B.; Hitchcock, Peter B.; McKerrecher, Darren; Titcomb, Lisa R.; Williams, Meredith R.V.
Journal of Organometallic Chemistry, 2001 , vol. 617-618, p. 635 - 639
反应条件
1: piperazine With [2,2']bipyridinyl; nickel diacetate; sodium hydride; 1,1-dimethylpropan-1-ol in tetrahydrofuran T=65°C; 2 h; 2: 4-methyl-chlorobenzene With styrene in tetrahydrofuran T=65°C; 6.5 h;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924
反应条件
1: in diethylene glycol dimethyl ether 16 h; RefluxInert atmosphere; 2: With water; sodium carbonate 1 h;
参考文献
Anastasiadis, Charalampos; Hogarth, Graeme; Wilton-Ely, James D.E.T.
Inorganica Chimica Acta, 2010 , vol. 363, # 13 p. 3222 - 3228
反应条件
1: 70 percent / NaH/t-AmONa; styrene; 2,2'-bipyridine / Ni(0) / tetrahydrofuran / 11 h / Heating 2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 1999 , vol. 55, # 44 p. 12829 - 12842
反应条件
sodium t-butanolate in 1,4-dioxane T=90°C; Buchwald-Hartwig Coupling; 3 h; Inert atmosphere; TimeConcentration;
参考文献
Christensen, Henrik; Kiil, Soren; Dam-Johansen, Kim; Nielsen, Ole; Sommer, Michael B.
Organic Process Research and Development, 2006 , vol. 10, # 4 p. 762 - 769
参考文献
Fujii et al.
Yakugaku Zasshi, 1954 , vol. 74, p. 1049
Chem.Abstr., 1955 , p. 11666
Full Text Show Details
Pollard; Wicker
Journal of the American Chemical Society, 1954 , vol. 76, p. 1853
反应条件
potassium carbonate in methanol; water 20 h;
参考文献
Kawaguchi, Mamoru; Hayashi, Osamu; Kanamoto, Masahiro; Hamada, Masayuki; Yamamoto, Yukio; Oda, Jun'ichi
Agricultural and Biological Chemistry, 1987 , vol. 51, # 2 p. 435 - 440
参考文献
Agarwal, Kamlesh C.
Journal of the Indian Chemical Society, 1980 , vol. 57, # 11 p. 1170 - 1171
