4-(4-氟苯基)-4-氧代丁酸甲酯合成路线 （共 7 条）
反应条件
sulfuric acid in methanol; ethyl acetate
参考文献
CytoMed Incorporated
Patent: US6201016 B1, 2001 ;
反应条件
pyrrolidine; 1,3-bis-(diphenylphosphino)propane; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide T=115°C; Heck reaction; 6 h; Molecular sieve;
参考文献
Ruan, Jiwu; Saidi, Ourida; Iggo, Jonathan A.; Xiao, Jianliang
Journal of the American Chemical Society, 2008 , vol. 130, # 32 p. 10510 - 10511
参考文献
PanThera Biopharma, LLC
Patent: US2010/286125 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
triethylamine; 5-(2-hydroxyethyl)-4-methyl-3-(phenylmethyl)thiazolium chloride in various solvent(s) T=80°C; Stetter reaction; 12 h; Product distribution; Further Variations:SolventsCatalysts;
参考文献
Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334
参考文献
BDH Pharmaceuticals Limited
Patent: US3975388 A1, 1976 ;
反应条件
1: 83 percent / p-TsOH / benzene / 20 h / Heating 2: 93 percent / DIBAL-H / CH2Cl2; tetrahydrofuran / 1 h / -78 °C 3: 78 percent / acetic acid; NaCNBH3 / methanol / 30 h / 20 °C 4: 65 percent / conc. HCl / methanol / 2 h / Heating View Scheme
参考文献
Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334
反应条件
1: 83 percent / p-TsOH / benzene / 20 h / Heating
2: 93 percent / DIBAL-H / CH2Cl2; tetrahydrofuran / 1 h / -78 °C
3: 78 percent / acetic acid; NaCNBH3 / methanol / 30 h / 20 °C
View Scheme
参考文献
Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334
