1-(2-甲基苯基)哌嗪合成路线 （共 33 条）
反应条件
(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran; toluene T=80 - 90°C; 48 h;
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh; Shen, Lan; Anderson Evans; Goodman, Andrew
Tetrahedron Letters, 2002 , vol. 43, # 18 p. 3359 - 3363
反应条件
1: piperazine With [2,2']bipyridinyl; 1,1-dimethylpropan-1-ol; nickel diacetate in tetrahydrofuran T=63°C; complex formation; 2 h; 2: ortho-chlorotoluene With styrene in tetrahydrofuran Arylation; 8 h; Heating;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924
反应条件
1: piperazine With [2,2']bipyridinyl; 1,1-dimethylpropan-1-ol; nickel diacetate in tetrahydrofuran T=63°C; complex formation; 2 h; 2: ortho-chlorotoluene With styrene in tetrahydrofuran Arylation; 12 h; Heating;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924
反应条件
bis (triortho-tolylphosphine)palladium(II) chloride; sodium t-butanolate in 1,4-dioxane T=60°C;
参考文献
Zhao, Shu-Hai; Miller, Aubry K.; Berger, Jacob; Flippin, Lee A.
Tetrahedron Letters, 1996 , vol. 37, # 26 p. 4463 - 4466
参考文献
Jia, Jian-Min; Liu, Fang; Xu, Xiao-Li; Guo, Xiao-Ke; Jiang, Fen; Cherfaoui, Bahidja; Sun, Hao-Peng; You, Qi-Dong
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1557 - 1561
反应条件
sodium t-butanolate; [Pd2(dba)2]; tri-tert-butyl phosphine in o-xylene T=120°C; Yield given. Yields of byproduct given;
参考文献
Nishiyama, Masakazu; Yamamoto, Toshihide; Koie, Yasuyuki
Tetrahedron Letters, 1998 , vol. 39, # 7 p. 617 - 620
反应条件
in various solvent(s) T=150°C;
参考文献
Liu, Kevin G.; Robichaud, Albert J.
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7921 - 7922
反应条件
tris-(dibenzylideneacetone)dipalladium(0)
参考文献
Tosoh Corporation
Patent: US5929281 A1, 1999 ;
参考文献
Science et Organisation
Patent: US5084456 A1, 1992 ;
参考文献
Agarwal, Kamlesh C.
Journal of the Indian Chemical Society, 1980 , vol. 57, # 11 p. 1170 - 1171
