反应条件
1: 2-Bromo-5-fluoro-benzoic acid With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.0833333 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 22 h;
参考文献
ABBOTT LABORATORIES; AKRITOPOULOU-ZANZE, Irini; BRAJE, Wilfried; DJURIC, Stevan, W.; WILSON, Noel, S.; TURNER, Sean, C.; KRUGER, Albert, W.; RELO, Ana-Lucia; SHEKHAR, Shashank; WELCH, Dennie, S.; ZHAO, Hongyu; GANDARILLA, Jorge; GASIECKI, Alan, F.; LI, Huanqiu; THOMPSON, Christina, M.; ZHANG, Min
Patent: WO2010/135560 A1, 2010 ;
Location in patent: Page/Page column 135-136 ;