1: potassium carbonate / 2-methyl tetrahydrofuran / Reflux 2: methyltretrahydrofuran, 2- / 75 °C 3: hydrogenchloride / water; tetrahydrofuran / 0.25 h / 65 °C View Scheme

1.1: potassium carbonate / 2-methyl tetrahydrofuran / Reflux 2.1: methyltretrahydrofuran, 2- / 75 °C 3.1: hydrogenchloride / water; tetrahydrofuran / 0.25 h / 65 °C 4.1: sodium hydrogensulfite; water; hydrogen bromide; acetic acid / 2 h / Reflux 5.1: sodium carbonate / o-xylene; water / 70 - 80 °C 5.2: Reflux 5.3: 15 - 55 °C 6.1: ammonia / cyclohexane; water / Reflux View Scheme

(S)-(+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine in water; acetonitrile T=0 - 5°C; 2 h;

1.1: potassium carbonate / 2-methyl tetrahydrofuran / Reflux 2.1: methyltretrahydrofuran, 2- / 75 °C 3.1: hydrogenchloride / water; tetrahydrofuran / 0.25 h / 65 °C 4.1: sodium hydrogensulfite; water; hydrogen bromide; acetic acid / 2 h / Reflux 5.1: sodium carbonate / o-xylene; water / 70 - 80 °C 5.2: Reflux 5.3: 15 - 55 °C View Scheme

1: With sodium acetate; sodium tris(acetoxy)borohydride; acetic acid in tetrahydrofuran T=0 - 10°C; 2: With sodium hydroxide in tetrahydrofuran; water T=0 - 20°C; 0.5 h; 3: With hydrogenchloride in tetrahydrofuran; water T=10 - 50°C; 1.33333 h;

1: With lauryl mercaptan in ethyl acetate Inert atmosphereReflux; 2: With 2,2'-azo-bisisobutyronitrile in ethyl acetate 0.583333 h; Inert atmosphereReflux; 3: With hydrogenchloride in water; ethyl acetate 0.0833333 h; Reflux;

1: With acetic acid in 1,2-dichloro-ethane 0.5 h; Inert atmosphere; 2: With sodium cyanoborohydride in methanol; 1,2-dichloro-ethane T=20°C; 3: With hydrogenchloride in diethyl ether; ethyl acetate

hydrogenchloride in diethyl ether; ethyl acetate

1: (S)-(+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine / acetonitrile; water / 2 h / 0 - 5 °C 2: hydrogen bromide / acetic acid / 3 h / |Reflux 3: sodium hydroxide / water / 40 °C / pH 12.5 View Scheme

potassium carbonate in 2-methyl tetrahydrofuran Reflux; Product distribution / selectivity;