5-硝基-3H-1,3-苯并恶唑-2-酮合成路线 （共 8 条）
反应条件
Lawesson's reagent in xylene 5 h; Heating;
参考文献
Shridhar, D. R.; Jogibhukta, M.; Shanthan Rao, P.; Handa, Vijay K.
Synthesis, 1983 , # 11 p. 936 - 937
反应条件
1: 4-nitro-1,3-benzoxazolidin-2-one With sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; 1.75 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; Inert atmosphere;
参考文献
Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius
Patent: US2010/249124 A1, 2010 ;
Location in patent: Page/Page column 64 ;
US 20100249124 A1
反应条件
sodium hydride 1.) DMF, 2.) DMF, 95 deg C, 30 min.; Yield given. Multistep reaction;
参考文献
Abdelaal; Kong; Bauer
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 5 p. 1069 - 1076
参考文献
Zinner et al.
Chemische Berichte, 1959 , vol. 92, p. 407,410
反应条件
(i) KOH, EtOCH2CH2OH, (ii) /BRN= 605278/; Multistep reaction;
参考文献
Schering Corporation and Pharmacopeia Drug Discovery, Inc.
Patent: US2007/93477 A1, 2007 ;
Location in patent: Page/Page column 38 ;
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; methanol 6 h;
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
Location in patent: Page/Page column 165 ;
WO 2012/059932 A1
反应条件
1: H2 / Pd-C / aq. ethanol / 0.5 h / 2059.4 Torr 2: (i) aq. NaNO2, HBr, (ii) CuBr View Scheme
参考文献
Sam,J. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 408 - 410
参考文献
Gmelin Handbook: F: PerFHalOrg.1, 1.1.6.5.2, page 157 - 193
