R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
novozyme 435; water T=70°C; pH=7; 120 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
反应条件
novozyme 435; water T=70°C; pH=7; 144 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
反应条件
cross-linked enzyme aggregate of Candida antarctica lipase B; water T=40°C; pH=7; 48 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
反应条件
Candida antarctica lipase B immobilized on acrylic resin in toluene T=25°C; 0.0666667 h; Resolution of racemateFlow reactor; TemperatureTime;
参考文献
De Miranda, Amanda S.; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3332 - 3336
反应条件
1: NaH / dimethylformamide / 1.) 0 deg C, 1 h, 2.) ambient temp., 5 h 2: (S)-(-)-2-amino-3-methyl-1,1-diphenylbutanol*borane / tetrahydrofuran / 24 h / 30 °C View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
1: With {RuCl2(1-methyl-4-(1-methylethyl)benzene)}2; ethanolamine; potassium hydroxide in isopropyl alcohol T=25°C; 15 h; 2: With hydrogenchloride in methanol optical yield given as percent eestereoselective reaction;
参考文献
Guijarro, David; Pablo, Oscar; Yus, Miguel
Tetrahedron Letters, 2009 , vol. 50, # 38 p. 5386 - 5388
反应条件
sodium tetrahydroborate; zirconium tetrachloride; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol 1) THF, r.t., 20 h, 2) THF, r.t., 2 d; further reagent: ZrCl2-AlCl3; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Matsumoto, Takeshi; Sato, Daisuke; Inoue, Tsutomu
Journal of Organic Chemistry, 2000 , vol. 65, # 18 p. 5879 - 5881
反应条件
hexacarbonyl molybdenum in water; acetonitrile Heating;
参考文献
Yamazaki, Naoki; Atobe, Masakazu; Kibayashi, Chihiro
Tetrahedron Letters, 2001 , vol. 42, # 30 p. 5029 - 5032
反应条件
1: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 2: sodium ethoxide / ethanol / 1 h / 40 °C 3: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1: sodium ethoxide / ethanol / 1 h / 40 °C 2: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
