您好，欢迎来到魔法化学网！
| CAS号 : | 618-36-0 |
精确质量 : | 121.08900 |
| 分子式 : | C8H11N |
logP : | 2.40660 |
| 分子量 : | 121.18000 |
PSA : | 26.02000 |
α-苯乙胺 | |
1-phenylethylamine | |
618-36-0 | |
C8H11N | |
121.18000 | |
26.02000 | |
2.40660 | |
121.08900 |
|
1.525-1.527
|
|
|
液体
|
|
|
69ºC
|
|
|
188ºC
|
|
|
-65ºC
|
|
|
0.94
|
|
|
Stable, but absorbs carbon dioxide from the air. Store under an inert atmosphere. Incompatible with strong oxidizing agents, carbon dioxide.
|
|
|
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.
|
|
29214980
|
|
|
S26-S28-S36/37/39-S45
|
|
|
III
|
|
|
UN 2735
|
|
|
C
|
|
|
R21/22; R34
|
|
2933990090
|
|
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% | |
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
暂时无法加载合成路线，请稍后刷新重试 |
<p>3.制法: 于装有搅拌器、温度计、韦氏分馏柱的反应瓶中,加入甲酸铵126g(2.0mol),苯乙酮<br>(2)72g(0.6mol),搅拌下油浴加热至150～155℃,开始发生反应①。继续缓缓加热至185℃(约2h),这时不断有水和苯乙酮蒸出来。将馏出物中的苯乙酮分出,不必干燥,加到反应瓶中继续于185℃左右反应3h,生成中间体<br>(3)。镏出液用甲苯提取回收苯乙酮。反应液中加入水75mL,分出有机层,水层以甲苯提取(20ml<br>×2),合并有机层与甲苯提取液,加入75mL盐酸。蒸去甲苯,并煮沸40min,1-苯乙基甲酰胺水解成1-苯基乙胺盐酸盐。冷却,甲苯提取除去未反应的苯乙酮。水层加入65g氢氧化钠溶于125mL水配成的溶液,水蒸气蒸馏。蒸出约500mL时,绝大部分胺己蒸出来。用甲苯提取(30mL<br>×5),提取液用固体氢氧化钠干燥,然后进行分馏,收集180～190℃的馏分,得DL-1-苯基乙胺<br>(1)②43g,收率59%。注:①该反应为Leukart反应,可能的机理如下。②工业上可由苯乙酮与氨,在Raney Ni存在下于150℃、24～35MPa压力下来合成DL-1-苯基乙胺,收率较高。 </p> | |
<p>用作医药、染料、香料、乳化剂等的中间体。</p> |
