R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
1: toluene; diethyl ether / 0.42 h / 0 °C 2: 90 percent / Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C View Scheme
参考文献
Yamazaki, Naoki; Atobe, Masakazu; Kibayashi, Chihiro
Tetrahedron Letters, 2001 , vol. 42, # 30 p. 5029 - 5032
反应条件
1: benzene 2: 79 percent / tetrahydrofuran / 40 deg C, 6 h, RT, 37 h 3: conc. HCl, hydrogen / 10percent Pd-carbon / ethanol / 8 h / 50 - 60 °C / 4413.05 Torr View Scheme
参考文献
Takahashi; Tomita; Noguchi
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3387 - 3391
反应条件
1: 79 percent / tetrahydrofuran / 40 deg C, 6 h, RT, 37 h 2: conc. HCl, hydrogen / 10percent Pd-carbon / ethanol / 8 h / 50 - 60 °C / 4413.05 Torr View Scheme
参考文献
Takahashi; Tomita; Noguchi
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3387 - 3391
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1-n-butyl-3-methylimidazolium hexafluorophosphate in n-heptane T=35°C; Resolution of racemateMicrobiological reaction;
参考文献
De Miranda, Amanda S.; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3332 - 3336
反应条件
dimethylsulfide borane complex; (S)-(-)-2-amino-1,1,2-triphenylethanol in dichloromethane T=-10°C; 15 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ortiz-Marciales, Margarita; Tirado, Liz M.; Colon, Roberto; Ufret, Maria L.; Figueroa, Ruth; Lebron, Marisabel; DeJesus, Melvin; Martinez, Johanna; Malave, Tania
Synthetic Communications, 1998 , vol. 28, # 21 p. 4067 - 4075
反应条件
1: With sodium tetrahydridoaluminate; (-)-(R,R)-TADDOL in tetrahydrofuran T=-70°C; 2: With hydrogenchloride in methanol T=20°C; 3 h; Title compound not separated from byproducts;
参考文献
Vinogradov; Gorshkova; Chel'tsova; Pavlov; Razmanov; Ferapontov; Malyshev; Heise
Russian Chemical Bulletin, 2003 , vol. 52, # 2 p. 471 - 479
