R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
n-butyllithium in tetrahydrofuran T=0°C; 2 h; Inert atmosphere;
参考文献
Andrade, Leandro H.; Silva, Alexandre V.; Milani, Priscila; Koszelewski, Dominik; Kroutil, Wolfgang
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 9 p. 2043 - 2051
反应条件
n-butyllithium in tetrahydrofuran T=0°C; 2 h; Inert atmosphere;
参考文献
Andrade, Leandro H.; Silva, Alexandre V.; Milani, Priscila; Koszelewski, Dominik; Kroutil, Wolfgang
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 9 p. 2043 - 2051
反应条件
n-butyllithium in tetrahydrofuran T=0°C; 2 h; Inert atmosphere;
参考文献
Andrade, Leandro H.; Silva, Alexandre V.; Milani, Priscila; Koszelewski, Dominik; Kroutil, Wolfgang
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 9 p. 2043 - 2051
反应条件
potassium carbonate in methanol; water T=20°C; 48 h;
参考文献
Allwein, Shawn P.; McWilliams, J. Christopher; Secord, Elizabeth A.; Mowrey, Dale R.; Nelson, Todd D.; Kress, Michael H.
Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6409 - 6412
反应条件
1: 80 percent / H2 / (MeBPE)Rh(COD)BF4 / ethanol / 23 °C / 4654.33 Torr 2: 100 percent Chromat. / K2CO3 / methanol; H2O / 48 h / 20 °C View Scheme
参考文献
Allwein, Shawn P.; McWilliams, J. Christopher; Secord, Elizabeth A.; Mowrey, Dale R.; Nelson, Todd D.; Kress, Michael H.
Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6409 - 6412
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
novozyme 435 in ethylene glycol dimethyl ether T=40°C; 118 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
反应条件
novozyme 435 in ethylene glycol dimethyl ether T=40°C; 128 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
反应条件
novozyme 435 in ethylene glycol dimethyl ether T=40°C; 200 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
反应条件
novozyme 435 in ethylene glycol dimethyl ether T=40°C; 216 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
