R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
pyridoxal 5'-phosphate in aq. phosphate buffer T=30°C; pH=7.5; 24 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Paeivioe, Mari; Kanerva, Liisa T.
Process Biochemistry, 2013 , vol. 48, # 10 p. 1488 - 1494
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. buffer T=37°C; pH=7.4; 12 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
hydrogenchloride; (+)-ketopinic acid; water; lithium diisopropyl amide Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Shin, Jong-Shik; Kim, Byung-Gee
Bioscience, Biotechnology and Biochemistry, 2001 , vol. 65, # 8 p. 1782 - 1788
反应条件
water in dimethyl sulfoxide T=30°C; pH=7; 18 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Leisch, Hannes; Grosse, Stephan; Iwaki, Hiroaki; Hasegawa, Yoshie; Lau, Peter C.K.
Canadian Journal of Chemistry, 2012 , vol. 90, # 1 p. 39 - 45
反应条件
1: With titanium(IV) isopropylate; hydrogen; iodine; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (S,S)-f-binaphane in dichloromethane T=20°C; P=51714.8 Torr; 10 h; 2: With ammonium cerium(IV) nitrate in methanol; water T=0°C; 6 h; Title compound not separated from byproducts;
参考文献
Chi, Yongxiang; Zhou, Yong-Gui; Zhang, Xumu
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 4120 - 4122
反应条件
1: 85 percent / NaH / dimethylformamide / 20 °C 2: BH3*DMS / enantiopure spiroborate ester / tetrahydrofuran / 36 h / 25 °C View Scheme
参考文献
Krzeminski, Marek P.; Zaidlewicz, Marek
Tetrahedron Asymmetry, 2003 , vol. 14, # 11 p. 1463 - 1466
反应条件
sodium hydroxide; triethanolamine in water T=120°C; 6 h; optical yield given as percent ee;
参考文献
Ditrich, Klaus
Synthesis, 2008 , # 14 SPEC. ISS. art. no. C01108SS, p. 2283 - 2287
反应条件
1: With {RuCl2(1-methyl-4-(1-methylethyl)benzene)}2; potassium tert-butylate; (1S,2R)-1-aminoindan-2-ol in isopropyl alcohol T=40°C; 2 h; Molecular sieve; 2: With hydrogenchloride in methanol optical yield given as percent eestereoselective reaction;
参考文献
Guijarro, David; Pablo, Oscar; Yus, Miguel
Tetrahedron Letters, 2009 , vol. 50, # 38 p. 5386 - 5388
反应条件
Novozym 435 in toluene T=23°C; 6 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Paeivioe, Mari; Perkioe, Paeivi; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2012 , vol. 23, # 3-4 p. 230 - 236
反应条件
Novozym 435 in toluene T=23°C; 6 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Paeivioe, Mari; Perkioe, Paeivi; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2012 , vol. 23, # 3-4 p. 230 - 236
