R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
sodium hydroxide; triethanolamine in water T=120°C; 3 h;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2006/87321 A1, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
1: in toluene 24 h; Reflux; 2: With hydrogenchloride; water in toluene
参考文献
Davies, Stephen G.; Mortimer, Duncan A. B.; Mulvaney, Andrew W.; Russell, Angela J.; Skarphedinsson, Hjalmar; Smith, Andrew D.; Vickers, Richard J.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 9 p. 1625 - 1634
反应条件
coated protease in 3-methyl pentan-3-ol T=21°C; 7 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Queyroy, Severine; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1759 - 1764
反应条件
samarium diiodide; hydrogen; 1.) <(COD)Rh(1,2-bis((2R,5R)-2,5-diethylphospholano)-benzene)>+CF3SO3- 1.)-10 deg C, 24 h, isopropanol, 60 psi; 2.) methanol, THF, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Burk, Mark J.; Martinez, Jose P.; Feaster, John E.; Cosford, Nick
Tetrahedron, 1994 , vol. 50, # 15 p. 4399 - 4428
反应条件
sodium tetrahydroborate; (S)-valinol; zirconium tetrachloride in tetrahydrofuran 48 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Sakurai, Yoshiki; Shimizu, Koji; Ito, Koichi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1859 - 1863
反应条件
hydrogenchloride in ethanol 6 h; Ambient temperature; Yield given;
参考文献
Mokhallalati; Pridgen
Synthetic Communications, 1993 , vol. 23, # 14 p. 2055 - 2064
反应条件
glutaryl-7-aminocephalosporanic acid acylase in water T=25°C; pH=7.0; Title compound not separated from byproducts;
参考文献
Raimondi, Stefano; Monti, Daniela; Pagnoni, Ugo Maria; Riva, Sergio
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 6-7 p. 783 - 789
反应条件
1: MgBr2 / tetrahydrofuran; diethyl ether / 24 h / 20 °C 2: aq. AcOH / tetrahydrofuran / 24 h / 40 °C View Scheme
参考文献
Pizzonero, Mathieu; Dumas, Francoise; d'Angelo, Jean
Heterocycles, 2005 , vol. 66, # 1 p. 31 - 37
反应条件
1: 34 percent / CHCl3 / 7 h / Heating 2: 2) KOH / 1) thermal decomposition; 2) H2O, EtOH, reflux, 40 h View Scheme
参考文献
Chrzanowska; Schonenberger; Brossi
Helvetica Chimica Acta, 1987 , vol. 70, # 7 p. 1721 - 1731
反应条件
1: Pb(OAc)4 / methanol; CH2Cl2 / 0.17 h / 0 °C 2: conc. aq. HCl / ethanol / 6 h / Ambient temperature View Scheme
参考文献
Mokhallalati; Pridgen
Synthetic Communications, 1993 , vol. 23, # 14 p. 2055 - 2064
