3,4-二氟苯胺合成路线

参考文献

SANKYO COMPANY, LIMITED
Patent: WO2006/109633 A1, 2006 ;
Location in patent: Page/Page column 185-186 ;

766-38-13,4-二溴-5-羟基呋喃-2(5h)-酮+

3863-11-43,4-二氟苯胺

221031-08-94,5-二溴-2-(3,4-二氟苯基)-3(2H)-哒嗪酮

参考文献

Zhang, Ji; Morton, Howard E.; Ji, Jianguo
Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8733 - 8735

3863-11-43,4-二氟苯胺

221031-08-94,5-二溴-2-(3,4-二氟苯基)-3(2H)-哒嗪酮

参考文献

Kerdesky, Francis A. J.; Leanna, M. Robert; Zhang, Ji; Li, Wenke; Lallaman, John E.; Ji, Jianguo; Morton, Howard E.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 512 - 517

541-41-3氯甲酸乙酯+

3863-11-43,4-二氟苯胺

2145-85-9

参考文献

SANOFI-AVENTIS; CHOI-SLEDESKI, Yong-Mi; GARDNER, Charles, J.; LIANG, Guyan; POLI, Gregory, B.; SHUM, Patrick, Wai-Kwok; STOKLOSA, Gregory, T.; ZHAO, Zhicheng
Patent: WO2011/22449 A1, 2011 ;
Location in patent: Page/Page column 99 ;
WO 2011/022449 A1

参考文献

Zhong, Weihui; Liu, Zhenyu; Yu, Chuanming; Su, Weike
Synlett, 2008 , # 18 p. 2888 - 2892

参考文献

Zhong, Weihui; Liu, Zhenyu; Yu, Chuanming; Su, Weike
Synlett, 2008 , # 18 p. 2888 - 2892

108-23-6氯甲酸异丙酯+

3863-11-43,4-二氟苯胺

2342-65-6

参考文献

Finger,G.C. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 572 - 573

3863-11-43,4-二氟苯胺

85462-60-82-甲基-4,5-二氟吲哚

参考文献

Ishikawa; Uno; Miyamoto; Ueda; Tamaoka; Tominaga; Nakagawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2459 - 2462

3863-11-43,4-二氟苯胺

78056-39-04,5-二氟-2-硝基苯胺

参考文献

El-Abadelah, Mustafa M.; Nazer, Musa Z.; El-Abadla, Naser S.; Meier, Herbert
Heterocycles, 1995 , vol. 41, # 10 p. 2203 - 2220

3282-30-2三甲基乙酰氯+

3863-11-43,4-二氟苯胺

参考文献

Bristol-Myers Squibb Pharma Company
Patent: EP929533 B1, 2003 ;