4-甲基-5-羟甲基咪唑盐酸盐合成路线 (共 12 条)
反应条件
in 1-methyl-pyrrolidin-2-one T=140°C; 4 h; Inert atmosphere;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/113478 A1, 2010 ;
Location in patent: Page/Page column 13 ;
反应条件
p-toluenesulfonic acid monohydrate in 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane
参考文献
Glaxo Group Limited
Patent: US5276050 A1, 1994 ;