4-甲基-5-羟甲基咪唑盐酸盐

4-甲基-5-羟甲基咪唑盐酸盐

4-Methyl-5-imidazolemethanol hydrochloride

38585-62-5

C5H9ClN2O

148.59100

48.91000

1.01240

148.04000

灰白色固体粉末

189.1ºC

389.1ºC at 760 mmHg

233 °C (dec.)(lit.)

Stable under normal temperatures and pressures.

Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

GHS07

警告

H315; H319; H335

P261; P305 + P351 + P338

3

S26-S37/39

Xi

R36/37/38

2933290090

2933990090

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

<p>将α-氯乙酰乙酸乙酯、甲酰胺、工业硫酸和水混合搅拌升温至140±5℃，保温5小时后降温至约50℃，用液碱调节pH至9，冷至10-0℃，静置过夜后抽滤，水洗至pH=7.5，滤干。将滤饼加丙酮浸泡洗涤，滤干，干燥得4-甲基-5-咪唑甲酸乙酯。将其加入液氨和金属钠条的混合物中，搅拌下滴加甲醇，加入氯化铵，加热赶氨至尽。加入用氯化氢饱和的异丙醇溶液，回流1.5小时。降温至50℃，通入干燥氯化氢至反应液pH约2.5，降温至40℃，抽滤，用异丙醇洗涤，洗滤液合并浓缩后冷至0℃以下，静置过夜，抽滤，用丙酮浸泡洗涤，干燥，得成品。收率89%。</p>

<p>药物甲氰咪胍（Cimetidine）的中间体。</p>