4-溴苯-1,2-二羧酸二乙基酯合成路线 （共 9 条）
参考文献
Baker
Journal of the Chemical Society, 1928 , p. 2829
反应条件
sulfuric acid
T=79°C; 0.5 h; Microwave radiation;
参考文献
Dublanchet, Anne-Claude; Compere, Delphine; Cluzeau, Philippe; Blais, Stephane; Denis, Alexis; Ducrot, Pierre; Courte, Karine; Descamps, Sophie
Patent: US2004/72871 A1, 2004 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With hydrogenchloride; sodium nitrite
T=0°C; Diazotization;
2: With hydrogen bromide; copper(I) bromide
Bromination; Heating;
参考文献
Nandy, Partha; Avramis, Vassilios I.; Lien, Eric J.
Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 664 - 679
反应条件
bromine trifluoride; bromine
T=0 - 10°C;
参考文献
Rozen, Shlomo; Lerman, Ori
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 239 - 240
反应条件
1.1: 75 percent / hydrogen / 10 percent Pd on charcoal / ethanol / 5 h / 20 °C / 1551.44 Torr
2.1: NaNO2; HCl / 0 °C
2.2: 35 percent / CuBr; HBr / Heating
View Scheme
参考文献
Nandy, Partha; Avramis, Vassilios I.; Lien, Eric J.
Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 664 - 679
反应条件
1.1: 78 percent / HCl(g) / 72 h / 80 °C
2.1: 75 percent / hydrogen / 10 percent Pd on charcoal / ethanol / 5 h / 20 °C / 1551.44 Torr
3.1: NaNO2; HCl / 0 °C
3.2: 35 percent / CuBr; HBr / Heating
View Scheme
参考文献
Nandy, Partha; Avramis, Vassilios I.; Lien, Eric J.
Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 664 - 679
反应条件
thionyl chloride
2 h; Reflux;
参考文献
Braslau, Rebecca; Schaeffner, Friederike; Earla, Aruna
Journal of Polymer Science, Part A: Polymer Chemistry, 2013 , vol. 51, # 5 p. 1175 - 1184
反应条件
1: sodium hydroxide; bromine / water / 7 h / 90 °C
2: thionyl chloride / 2 h / |Reflux
View Scheme
参考文献
Braslau, Rebecca; Schaeffner, Friederike; Earla, Aruna
Journal of Polymer Science, Part A: Polymer Chemistry, 2013 , vol. 51, # 5 p. 1175 - 1184
反应条件
water; potassium hydroxide in acetonitrile
T=60°C;
参考文献
HEFFERNAN, Michele, L., R.; HARDY, Larry, Wendell; WU, Frank, Xinhe; SARASWAT, Lakshmi, D.; SPEAR, Kerry, L.
Patent: WO2012/170845 A2, 2012 ;
Location in patent: Page/Page column 88 ;
WO 2012/170845 A2
