4-氯-4`-甲基苯丁酮合成路线 （共 12 条）
反应条件
AlCl3, aluminium chloride in water; toluene T=2 - 4°C; 30 h;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 24 ;
反应条件
aluminium trichloride in water T=2 - 4°C; 30.25 h;
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6340761 B1, 2002 ;
Location in patent: Page column 24-25 ;
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=80°C; 3 h;
参考文献
Rao, Maddali L.N.; Venkatesh, Varadhachari; Banerjee, Debasis
Tetrahedron, 2007 , vol. 63, # 52 p. 12917 - 12926
反应条件
iron silicate T=25°C;
参考文献
Borate, Hanumant B.; Gaikwad, Abaji G.; Maujan, Suleman R.; Sawargave, Sangmeshwer P.; Kalal, Kamalakar M.
Tetrahedron Letters, 2007 , vol. 48, # 28 p. 4869 - 4872
反应条件
in diethyl ether T=-40 - 20°C; Inert atmosphere;
参考文献
Pablo, Oscar; Guijarro, David; Yus, Miguel
Journal of Organic Chemistry, 2013 , vol. 78, # 18 p. 9181 - 9189
反应条件
potassium hydroxide in methanol T=8 - 10°C; 0.333333 h;
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6340761 B1, 2002 ;
Location in patent: Page column 25-26 ;
反应条件
1.1: dimethylformamide / 22 h / 5 °C 2.1: H2SO4 / methanol / 1 h / Heating 2.2: chloranil / benzene / 2 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 22 p. 4729 - 4742
反应条件
1: titanium tetraethoxide / neat (no solvent) / 72 °C / |Inert atmosphere 2: [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; 2-amino-2-methyl-propan-1-ol; isopropyl alcohol; potassium tert-butylate / 2 h / 50 °C / |Molecular sieve; |Inert atmosphere 3: potassium tert-butylate / isopropyl alcohol / 1 h / 50 °C / |Inert atmosphere 4: hydrogenchloride / methanol; water / |Inert atmosphere View Scheme
参考文献
Pablo, Oscar; Guijarro, David; Yus, Miguel
Journal of Organic Chemistry, 2013 , vol. 78, # 18 p. 9181 - 9189
反应条件
in N,N-dimethyl-formamide
T=5°C; 22 h;
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: dimethylformamide / 22 h / 5 °C
2.1: H2SO4 / methanol / 1 h / Heating
2.2: chloranil / benzene / 2 h / Heating
3.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating
4.1: 76 percent / NaOH; Ag2O / H2O / 20 - 50 °C
5.1: 95 percent / H2SO4 / toluene / 7 h / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
