4-氯丁酰氯

4-氯丁酰氯

4-Chlorobutyryl chloride

4635-59-0

C4H6Cl2O

140.99600

17.07000

1.77080

139.98000

n20/D 1.461(lit.)

透明液体

163 °F

173-174 °C(lit.)

-47 °C

1.26 g/mL at 25 °C(lit.)

3 mm Hg ( 20 °C)

Keep away from sources of ignition. Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container. Corrosives area.

EM1406000

1

29159080

6.1

S26-S28-S36/37/39-S45-S28A

II

UN 3390 6.1/PG 1

C

R22; R23; R35

2933990090

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

<p>1.其制备方法是将丁内酯、无水氯化锌和氯化亚砜置于反应瓶中,于55℃搅拌12h,减压蒸馏收集产品。 由γ-丁内酯经氯化而得。将γ-丁内酯和氯化锌搅拌升温,在55-60℃下反应1h。于60℃慢慢加入氯化亚砜,反应2h。在5-6h内升温至80℃。静置过夜,取上部清液常压蒸馏后再重蒸1次,收集馏分得4-氯丁酰氯。 <br>2.制法: 于装有搅拌器、温度计、滴液漏斗、回流冷凝器(连一导气管吸收氯化氢和二氧化硫)的反应瓶中,加入γ-丁内酯<br>(2)85g(1mol),新熔融过的氯化锌33g(0.24mol),滴加氯化亚砜143g(1.2mol),约20min加完。慢慢升温至60～70℃,搅拌反应12h,水泵抽去酸气后,用油泵减压蒸馏,收集69～71℃/1.4kPa的馏分,得4-氯丁酰氯<br>(1)105g,收率75%。nD251.465～1.4607。 </p>

<p>主要用于医药中间体。</p>