1,2-二甲基-1H-吲哚-3-甲醛合成路线 （共 22 条）
反应条件
1: N,N-dimethyl-formamide With oxalyl dichloride T=0°C; Vilsmeier-Haack Formylation; 1 h; 2: N-methyl-2-methylindole in N,N-dimethyl-formamide T=20°C; Vilsmeier-Haack Formylation; 5 h; 3: With sodium hydroxide in N,N-dimethyl-formamide T=100°C; Vilsmeier-Haack Formylation; 0.166667 h;
参考文献
Zheng, Jing; Deng, Lijuan; Chen, Minfeng; Xiao, Xuzhi; Xiao, Shengwei; Guo, Cuiping; Xiao, Gaokeng; Bai, Liangliang; Ye, Wencai; Zhang, Dongmei; Chen, Heru
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 158 - 167
反应条件
1,4-diaza-bicyclo[2.2.2]octane; dimethylsulfide; oxygen in dimethyl sulfoxide T=100°C; P=760.051 Torr; 4 h; chemoselective reaction;
参考文献
Wang, Yi-Feng; Zhang, Feng-Lian; Chiba, Shunsuke
Synthesis, 2012 , vol. 44, # 10 p. 1526 - 1534
反应条件
polymer-bound Rose Bengal; oxygen in chloroform T=-5°C; 1 h; Irradiation;
参考文献
Zhang; Khan; Foote
Journal of Organic Chemistry, 1993 , vol. 58, # 27 p. 7839 - 7847
反应条件
oxygen; copper dichloride in water; dimethyl sulfoxide T=120°C; 4 h;
参考文献
Chen, Jianbin; Liu, Bin; Liu, Dongfang; Liu, Shan; Cheng, Jiang
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 13 p. 2438 - 2442
反应条件
methanol; sodium hydroxide
参考文献
Leete
Journal of the American Chemical Society, 1959 , vol. 81, p. 6023,6025
反应条件
1,4-diaza-bicyclo[2.2.2]octane; oxygen; copper(II) bis(trifluoromethanesulfonate) T=100°C; P=760.051 Torr;
参考文献
Wang, Yi-Feng; Zhang, Feng-Lian; Chiba, Shunsuke
Synthesis, 2012 , vol. 44, # 10 p. 1526 - 1534
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in benzene 2 h;
参考文献
Jaisankar, Pichamuthu; Srinivasan
Synthesis, 2006 , # 14 p. 2413 - 2417
反应条件
1.1: NaH / dimethylformamide / 0.5 h / 0 °C 1.2: 97 percent / dimethylformamide / 16 h / 0 - 20 °C 2.1: 91 percent / POCl3 / 2 h / 20 °C View Scheme
参考文献
Leete
Journal of the American Chemical Society, 1959 , vol. 81, p. 6023,6025
参考文献
Liu, Yanbing; Gribble, Gordon W
Tetrahedron Letters, 2002 , vol. 43, # 40 p. 7135 - 7137
反应条件
1: 1.) 2,3-dichloro-5,6-dicyan-p-benzoquinone; 2.) potassium carbonate / 1.) tetrahydrofuran, water, room temperature, 10 h; 2.) 1 h 2: 1.) potassium hydroxide / 1.) DMSO, 0.5 h; 2.) room temperature, 2 h View Scheme
参考文献
Canoira; Gonzalo Rodriguez; Subirats; Escario; Jimenez; Martinez-Fernandez
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 1 p. 39 - 42
