2-氨基-4-甲基噻唑-5-甲酸甲酯合成路线 （共 7 条）
参考文献
Atkins, Elaine F.; Dabbs, Steven; Guy, Robert G.; Mahomed, Akbar A.; Mountford, Philip
Tetrahedron, 1994 , vol. 50, # 24 p. 7253 - 7264
反应条件
in ethanol T=20°C; 3 h; Inert atmosphere;
参考文献
Li, Ze; Khaliq, Mansoora; Zhou, Zhigang; Post, Carol Beth; Kuhn, Richard J.; Cushman, Mark
Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4660 - 4671
反应条件
potassium carbonate in tetrahydrofuran Cyclization; 36 h; Heating;
参考文献
Park, Young Seok; Kim, Kyongtae
Tetrahedron Letters, 1999 , vol. 40, # 35 p. 6439 - 6442
反应条件
1: 47 percent / tetrahydrofuran / 60 h / Heating 2: 98 percent / K2CO3 / tetrahydrofuran / 36 h / Heating View Scheme
参考文献
Park, Young Seok; Kim, Kyongtae
Tetrahedron Letters, 1999 , vol. 40, # 35 p. 6439 - 6442
参考文献
Sharma,S.C.
Indian Journal of Chemistry, 1966 , vol. 4, p. 33 - 36
反应条件
1: 2-bromoacetaldehyde diethyl acetal With hydrogenchloride in water T=20 - 80°C; 14.5 h; 2: With sodium hydrogencarbonate in water T=20°C; 2 h; 3: 2-amino-4-methylthiazole-5-carboxylic acid methyl ester in 1,4-dioxane; water T=20 - 100°C; 49.5 h;
参考文献
Actelion Phamaceuticals Ltd.
Patent: US2010/16401 A1, 2010 ;
Location in patent: Page/Page column 40 ;
反应条件
1: With sodium hydrogencarbonate in water T=20°C; 3 h; 2: in 1,4-dioxane; water T=20 - 100°C; 48.5 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/81399 A2, 2008 ;
Location in patent: Page/Page column 66 ;
WO 2008/081399 A2
