2-(2-氟苯基)-1-苯乙酮合成路线 （共 8 条）
反应条件
sodium t-butanolate; (IMes)Pd(NQ) in toluene
T=100°C; 24 h; Conversion of starting material;
参考文献
Karch, Ralf; Briel, Oliver; Kayser, Bernd; Beller, Matthias; Selvakumar, Kumaravel; Frisch, Anja; Zapf, Alexander
Patent: US2006/122398 A1, 2006 ;
Location in patent: Page/Page column 9 ;
反应条件
potassium phosphate; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in tetrahydrofuran; 1,4-dioxane; toluene
T=100°C; 18 h;
参考文献
Desai, Lopa V.; Ren, Danan T.; Rosner, Thorsten
Organic Letters, 2010 , vol. 12, # 5 p. 1032 - 1035
反应条件
potassium phosphate; Pd(OAc)2*n-butylbis(1-adamantyl)phosphine in 1,4-dioxane
T=100°C; 20 h;
参考文献
Ehrentraut, Andreas; Zapf, Alexander; Beller, Matthias
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 2 p. 209 - 217
反应条件
Ni(PCy3)2Cl2; sodium t-butanolate in N,N-dimethyl-formamide; toluene
T=100°C; Suzuki-Miyaura coupling; 1 h; Inert atmosphere;
参考文献
Huang, Kun; Li, Gang; Huang, Wei-Ping; Yu, Da-Gang; Shi, Zhang-Jie
Chemical Communications, 2011 , vol. 47, # 25 p. 7224 - 7226
反应条件
1: benzene / 24 h / Heating
2: benzene / 12 h / Heating
View Scheme
参考文献
Anstead, Gregory M.; Peterson, Chad S.; Pinney, Kevin G.; Wilson, Scott R.; Katzenellenbogen, John A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2726 - 2734
反应条件
1: benzene / 12 h / Heating
View Scheme
参考文献
Anstead, Gregory M.; Peterson, Chad S.; Pinney, Kevin G.; Wilson, Scott R.; Katzenellenbogen, John A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2726 - 2734
反应条件
1: triethylamine / dichloromethane / 20 °C / Inert atmosphere
2: Ni(PCy3)2Cl2; sodium t-butanolate / N,N-dimethyl-formamide; toluene / 1 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Huang, Kun; Li, Gang; Huang, Wei-Ping; Yu, Da-Gang; Shi, Zhang-Jie
Chemical Communications, 2011 , vol. 47, # 25 p. 7224 - 7226
反应条件
Yield given. Multistep reaction;
参考文献
Anstead, Gregory M.; Peterson, Chad S.; Pinney, Kevin G.; Wilson, Scott R.; Katzenellenbogen, John A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2726 - 2734
